Division of Endocrinology, Diabetes and Metabolism, Department of Endocrinology and Metabolism, Loyola University Medical Center, Chicago, IL, USA.
Division of Endocrinology, Diabetes and Metabolism, Department of Endocrinology and Metabolism, Loyola University Medical Center, Maywood, IL, USA.
Endocrinol Metab Clin North Am. 2024 Dec;53(4):497-512. doi: 10.1016/j.ecl.2024.08.008. Epub 2024 Oct 5.
Osteoporosis is characterized by increased bone turnover and reduced bone mass, leading to skeletal fragility and heightened fracture risk. It is a growing public health concern with expectations for a continued significant rise of fractures by 50% in 2030. Diagnosis is typically based on body mineral density with a T-score of -2.5 or lower indicating osteoporosis. Treatment duration varies, and is determined by careful monitoring of fracture risk and timing for potential drug holidays. Emerging therapies and ongoing research continue to evolve the landscape of osteoporosis management, aiming to reduce fracture risk and improve patient outcomes.
骨质疏松症的特征是骨转换增加和骨量减少，导致骨骼脆弱和骨折风险增加。这是一个日益严重的公共健康问题，预计到 2030 年，骨折的发生率将继续显著上升 50%。诊断通常基于身体矿物质密度，T 分数为-2.5 或更低表示骨质疏松症。治疗持续时间不同，取决于骨折风险的仔细监测和潜在药物停药的时间。新兴疗法和正在进行的研究不断改变骨质疏松症管理的格局，旨在降低骨折风险，改善患者的预后。
