Yang Hongxi, Lu Zuolin, Fu Yinghong, Wu Tong, Hou Yabing
Department of Bioinformatics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
School of Population Medical and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Nutr Metab Cardiovasc Dis. 2025 Jan;35(1):103761. doi: 10.1016/j.numecd.2024.10.001. Epub 2024 Oct 5.
Stair climbing, a straightforward and impactful form of physical activity, has shown potential in reducing risks of cardiovascular disease and mortality. However, its association with the development of atrial fibrillation (AF) remains largely unexplored.
451,089 participants (mean age 56.5 years) without cardiovascular disease (year 2006-2010) were included from the UK Biobank study. Stair climbing data was collected through touchscreen questionnaire. AF cases were identified using ICD-10 code: I48 and were followed until February 1, 2022. Models adjusted for traditional cardiovascular risk factors. Over a median follow-up of 12.6 years, 23,660 (5.2 %) participants experienced new-onset AF. In multivariable-adjusted models, climbing 10-50, 60-100, 110-150, and ≥160 steps of stairs per day were associated with significant reductions in the risk of AF, compared to not climbing any stairs. The risk reduction appeared more pronounced in women than in men (P for interaction = 0.09). When compared to participants who climbed no stairs, the HRs for those who climbed 110-150 steps of stairs per day were 0.69 (95 % CI: 0.58-0.82) among those with low cardiorespiratory fitness, 0.71 (95 % CI: 0.57-0.88) among those with intermediate cardiorespiratory fitness, and 0.83 (95 % CI: 0.64-1.07) among those with high cardiorespiratory fitness.
Climbing stairs was associated with a reduction in AF risks. Significant interaction between cardiorespiratory fitness and stair climbing associated with incident AF was observed. Findings suggest that promoting regular stair climbing could be a potential target for preventing AF onset.
爬楼梯是一种简单且有效的体育活动形式，已显示出降低心血管疾病风险和死亡率的潜力。然而，其与心房颤动（AF）发生的关联在很大程度上仍未得到探索。
纳入英国生物银行研究中451,089名无心血管疾病的参与者（平均年龄56.5岁，时间为2006 - 2010年）。通过触摸屏问卷收集爬楼梯数据。使用国际疾病分类第十版（ICD - 10）编码I48识别AF病例，并随访至2022年2月1日。模型对传统心血管危险因素进行了调整。在中位随访12.6年期间，23,660名（5.2%）参与者发生了新发AF。在多变量调整模型中，与不爬楼梯相比，每天爬10 - 50级、60 - 100级、110 - 150级以及≥160级楼梯与AF风险显著降低相关。女性的风险降低似乎比男性更明显（交互作用P = 0.09）。与不爬楼梯的参与者相比，每天爬110 - 150级楼梯的参与者，在心肺功能低的人群中风险比（HR）为0.69（95%置信区间：0.58 - 0.82），在心肺功能中等的人群中为0.71（95%置信区间：0.57 - 0.88），在心肺功能高的人群中为0.83（95%置信区间：0.64 - 1.07）。
爬楼梯与AF风险降低相关。观察到心肺功能与爬楼梯和AF发病之间存在显著交互作用。研究结果表明，促进定期爬楼梯可能是预防AF发作的一个潜在目标。
