爬楼梯与动脉粥样硬化性心血管疾病发病风险：一项基于人群的前瞻性队列研究。

Stair climbing and the incidence of atherosclerotic cardiovascular disease: a population-based prospective cohort study.

机构信息

Department of Preventive Cardiology, National Cerebral and Cardiovascular Center.

Department of Public Health, Faculty of Medicine, Beni-Suef University.

出版信息

Environ Health Prev Med. 2023;28:60. doi: 10.1265/ehpm.23-00166.

DOI:10.1265/ehpm.23-00166

PMID:37899207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10613554/

Abstract

BACKGROUND

Stair climbing is a readily available form of physical activity with potential cardioprotective merits. Herein, we investigated the association between stair climbing and atherosclerotic cardiovascular disease (ASCVD) incidence among Japanese people.

METHODS

This prospective cohort study used data from 7,282 participants, aged 30-84 years, registered in the Suita Study and free from stroke and ischemic heart disease (IHD). Standard approaches were used to detect incident ASCVD events, including cerebral infarction and IHD, during follow-up. Stair climbing was assessed using a baseline questionnaire. We applied the Cox regression to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of incident ASCVD for climbing stairs in 20-39%, 40-59%, and ≥60% compared to <20% of the time. We adjusted the regression models for age, sex, body mass index, smoking, alcohol consumption, physical activity, hypertension, diabetes, atrial fibrillation, lipid profile, chronic kidney disease, and history of cardiac murmur or valvular diseases.

RESULTS

A total of 536 new ASCVD events were detected within a median follow-up period of 16.6 years. In the age- and sex-adjusted model, stair climbing 20-39%, 40-59%, and ≥60% of the time was associated with lower ASCVD incidence: HRs (95% CIs) = 0.72 (0.56, 0.92), 0.86 (0.68, 1.08), and 0.78 (0.61, 0.99), respectively (p-trend = 0.020). The corresponding associations were attenuated after adjusting for lifestyle and clinical factors: HRs (95% CIs) = 0.74 (0.58, 0.95), 0.90 (0.71, 1.13), and 0.89 (0.69, 1.13), respectively (p-trend = 0.152).

CONCLUSION

Frequent stair climbing was associated with lower ASCVD incidence; however, this association was partly explained by lifestyle and clinical factors of participants.

摘要

背景

爬楼梯是一种现成的体育活动形式，具有潜在的心脏保护作用。在此，我们研究了日本人爬楼梯与动脉粥样硬化性心血管疾病（ASCVD）发病率之间的关系。

方法

这项前瞻性队列研究使用了来自 Suita 研究的 7282 名年龄在 30-84 岁、无中风和缺血性心脏病（IHD）的参与者的数据。在随访期间，采用标准方法检测包括脑梗死和 IHD 在内的 ASCVD 事件的发生率。使用基线问卷评估爬楼梯情况。我们应用 Cox 回归计算与<20%时间相比，20-39%、40-59%和≥60%时间爬楼梯的 ASCVD 事件发生率的风险比（HR）和 95%置信区间（95%CI）。我们调整了回归模型，以考虑年龄、性别、体重指数、吸烟、饮酒、体力活动、高血压、糖尿病、心房颤动、血脂谱、慢性肾脏病以及心脏杂音或瓣膜疾病史。

结果

在中位随访 16.6 年期间，共检测到 536 例 ASCVD 新发病例。在年龄和性别调整模型中，20-39%、40-59%和≥60%时间爬楼梯与 ASCVD 发生率降低相关：HR（95%CI）分别为 0.72（0.56，0.92）、0.86（0.68，1.08）和 0.78（0.61，0.99）（趋势检验 p=0.020）。调整生活方式和临床因素后，相应的关联减弱：HR（95%CI）分别为 0.74（0.58，0.95）、0.90（0.71，1.13）和 0.89（0.69，1.13）（趋势检验 p=0.152）。