Condra M, Morales A, Surridge D H, Owen J A, Marshall P, Fenemore J
J Urol. 1986 Feb;135(2):280-2. doi: 10.1016/s0022-5347(17)45610-2.
We investigated the degree of congruence between outcome measures used to evaluate pharmacological treatment of impotence. After a comprehensive multidisciplinary assessment 17 patients were treated with an adrenergic blocker during an 8-week interval. Nocturnal penile tumescence recordings were made before treatment (as part of the assessment procedure) and at its conclusion. As part of a larger study the use of nocturnal penile tumescence monitoring has been examined as a possible outcome measure. Patient and partner self-reports also were used to evaluate treatment outcome. A comparison of patient and partner self-reports with nocturnal penile tumescence records showed little agreement between the 2 measures. These findings suggest that despite its intuitive appeal as an index of erectile function nocturnal penile tumescence recording is not a reliable index of therapeutic effectiveness. Furthermore, these findings lend support to the hypothesis that nocturnal penile tumescence and sexual erections may be separate phenomena, perhaps under the control of different mechanisms.
我们研究了用于评估阳痿药物治疗的结果指标之间的一致程度。经过全面的多学科评估后，17名患者在8周的时间内接受了肾上腺素能阻滞剂治疗。在治疗前（作为评估程序的一部分）和治疗结束时进行了夜间阴茎勃起记录。作为一项更大规模研究的一部分，夜间阴茎勃起监测的使用已被作为一种可能的结果指标进行了研究。患者及其伴侣的自我报告也被用于评估治疗结果。将患者及其伴侣的自我报告与夜间阴茎勃起记录进行比较，结果显示这两种指标之间几乎没有一致性。这些发现表明，尽管夜间阴茎勃起记录作为勃起功能指标具有直观吸引力，但它并不是治疗效果的可靠指标。此外，这些发现支持了这样一种假设，即夜间阴茎勃起和性交勃起可能是不同的现象，也许受不同机制的控制。
