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Modelling human liver disease: from steatotic liver disease to MASH-HCC.

作者信息

Stoess Christian, Feldstein Ariel E

机构信息

Department of Paediatric Gastroenterology, University of California San Diego, La Jolla, CA, USA.

Department of Surgery, School of Medicine and Health, Technical University of Munich, TUM University Hospital, Munich, Germany.

出版信息

Nat Rev Endocrinol. 2025 Jan;21(1):10-11. doi: 10.1038/s41574-024-01054-z.

DOI:10.1038/s41574-024-01054-z
PMID:39448831
Abstract
摘要

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本文引用的文献

1
A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma.一种用于代谢功能障碍相关脂肪性肝病和肝细胞癌的雄性小鼠模型。
Nat Commun. 2024 Aug 2;15(1):6506. doi: 10.1038/s41467-024-50660-y.
2
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).基于与人类代谢功能障碍相关的脂肪性肝病 (MASLD) 的接近程度，对鼠类饮食模型进行无偏排序。
Nat Metab. 2024 Jun;6(6):1178-1196. doi: 10.1038/s42255-024-01043-6. Epub 2024 Jun 12.
3
Protocol to generate human liver spheroids to study liver fibrosis induced by metabolic stress.
生成用于研究代谢应激诱导的肝纤维化的人源肝球体的方案。
STAR Protoc. 2024 Jun 21;5(2):103111. doi: 10.1016/j.xpro.2024.103111. Epub 2024 Jun 3.
4
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.一项评估 Resmetirom 治疗伴有肝纤维化的 NASH 的 3 期随机对照试验。
N Engl J Med. 2024 Feb 8;390(6):497-509. doi: 10.1056/NEJMoa2309000.
5
A researcher's guide to preclinical mouse NASH models.临床前小鼠非酒精性脂肪性肝炎（NASH）模型研究指南
Nat Metab. 2022 Dec;4(12):1632-1649. doi: 10.1038/s42255-022-00700-y. Epub 2022 Dec 20.
6
A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer.一种简单的饮食和化学诱导的 NASH 小鼠模型，其肝脂肪性肝炎、纤维化和肝癌的进展迅速。
J Hepatol. 2018 Aug;69(2):385-395. doi: 10.1016/j.jhep.2018.03.011. Epub 2018 Mar 21.
7
A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma.一种非酒精性脂肪性肝炎的小鼠模型，显示出糖尿病与肝细胞癌之间存在关联的证据。
Med Mol Morphol. 2013 Sep;46(3):141-52. doi: 10.1007/s00795-013-0016-1. Epub 2013 Feb 22.
8
Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis.糖尿病是一种进展因素，可导致非酒精性脂肪性肝炎的高脂肪喂养肥胖小鼠模型中的肝纤维化。
J Hepatol. 2011 Aug;55(2):435-44. doi: 10.1016/j.jhep.2010.10.039. Epub 2010 Dec 22.