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Stressing out with electrophiles.

作者信息

Stanton Caroline, Nutsch Kayla, Bollong Michael J

机构信息

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

出版信息

Nat Chem Biol. 2025 May;21(5):612-613. doi: 10.1038/s41589-024-01749-4.

DOI:10.1038/s41589-024-01749-4

PMID:39448843

Abstract

摘要

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相似文献

Stressing out with electrophiles.

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[Corticoliberin fragment CRF4-6 modifies rat behavior in opposite ways under stressing and non-stressing conditions].

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Environ Health Perspect. 1983 Mar;49:59-69. doi: 10.1289/ehp.834959.

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Acc Chem Res. 2020 Sep 15;53(9):1833-1845. doi: 10.1021/acs.accounts.0c00291. Epub 2020 Aug 25.

Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations.

Chem Res Toxicol. 2008 Feb;21(2):453-8. doi: 10.1021/tx7003618. Epub 2007 Dec 29.

本文引用的文献

Delineating cysteine-reactive compound modulation of cellular proteostasis processes.

Nat Chem Biol. 2025 May;21(5):693-705. doi: 10.1038/s41589-024-01760-9. Epub 2024 Oct 24.

Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly.

ACS Chem Biol. 2024 Feb 16;19(2):254-265. doi: 10.1021/acschembio.3c00330. Epub 2024 Jan 10.

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Cell Chem Biol. 2023 Oct 19;30(10):1295-1302.e4. doi: 10.1016/j.chembiol.2023.07.014. Epub 2023 Aug 23.

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Pharmaceuticals (Basel). 2023 Apr 28;16(5):663. doi: 10.3390/ph16050663.

CysDB: a human cysteine database based on experimental quantitative chemoproteomics.

Cell Chem Biol. 2023 Jun 15;30(6):683-698.e3. doi: 10.1016/j.chembiol.2023.04.004. Epub 2023 Apr 28.

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30.

Proteome-wide covalent ligand discovery in native biological systems.

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

Blood. 2011 Jun 9;117(23):6287-96. doi: 10.1182/blood-2011-01-328484. Epub 2011 Mar 21.

Quantitative reactivity profiling predicts functional cysteines in proteomes.

Nature. 2010 Dec 9;468(7325):790-5. doi: 10.1038/nature09472. Epub 2010 Nov 17.