Epidemiology, Medical Faculty, University of Augsburg, University Hospital of Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany.
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, 4006, Australia.
J Transl Med. 2024 Oct 24;22(1):962. doi: 10.1186/s12967-024-05765-9.
There is evidence that inflammatory arthritis in the form of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis are both positively and negatively associated with certain female-specific cancers. However, the study results are very heterogeneous.
Based on up to 375,814 European women, we performed an iterative two-sample Mendelian randomization to assess causal effects of the occurrence of the inflammatory arthritis on the risk of female-specific cancer in form of breast, endometrial, and ovarian cancer sites as well as their subtypes. Evidence was strengthened by using similar exposures for plausibility or by replication with a subsequent meta-analysis. P-values were Bonferroni adjusted.
Genetic liability to AS was associated with ovarian cancer (OR = 1.03; 95% CI: [1.01; 1.04]; [Formula: see text]=0.029) and liability to PsA with breast cancer (OR = 1.02; CI: [1.01; 1.04]; [Formula: see text]=0.002). Subgroup analyses revealed that the high-grade serous ovarian cancer (OR = 1.04; CI: [1.02; 1.06]; [Formula: see text]=0.015) and the ER- breast cancer (OR = 1.04; CI: [1.01; 1.07]; [Formula: see text]=0.118) appeared to drive the observed associations, respectively. No further associations were found between the remaining inflammatory arthritis phenotypes and female-specific cancers.
This study suggests that AS is a risk factor for ovarian cancer, while PsA is linked to an increased breast cancer risk. These results are important for physicians caring women with inflammatory arthritis to advise their patients on cancer screening and preventive measures.
有证据表明，强直性脊柱炎（AS）、银屑病关节炎（PsA）和类风湿性关节炎等炎症性关节炎与某些女性特有的癌症呈正相关和负相关。然而，研究结果差异很大。
基于多达 375814 名欧洲女性，我们进行了迭代两样本孟德尔随机化分析，以评估炎症性关节炎的发生对女性特定癌症（乳腺癌、子宫内膜癌和卵巢癌部位及其亚型）风险的因果影响。通过使用类似的暴露因素来进行合理性推断或通过随后的荟萃分析进行复制来加强证据。P 值进行了 Bonferroni 校正。
AS 的遗传易感性与卵巢癌相关（OR=1.03；95%CI：[1.01；1.04]；[Formula: see text]=0.029），PsA 的遗传易感性与乳腺癌相关（OR=1.02；CI：[1.01；1.04]；[Formula: see text]=0.002）。亚组分析表明，高级别浆液性卵巢癌（OR=1.04；CI：[1.02；1.06]；[Formula: see text]=0.015）和 ER-乳腺癌（OR=1.04；CI：[1.01；1.07]；[Formula: see text]=0.118）似乎分别驱动了观察到的关联。在剩余的炎症性关节炎表型与女性特有的癌症之间没有发现进一步的关联。
这项研究表明，AS 是卵巢癌的危险因素，而 PsA 与乳腺癌风险增加相关。这些结果对照顾炎症性关节炎女性的医生为患者提供癌症筛查和预防措施的建议非常重要。
