Ahmad Manal, Mohamed Abdulla, Amiras Dimitri, Siracusa Francesca, Shalhoub Joseph, Davies Alun Huw
Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, 4th Floor, North Wing, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom.
Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London, United Kingdom.
Clin Diabetes Endocrinol. 2024 Oct 25;10(1):31. doi: 10.1186/s40842-024-00194-5.
Sarcopenia is defined by low measures of muscle quantity, quality and reduced physical performance. It is associated with higher levels of frailty. Individuals with diabetes mellitus (DM) undergo sarcopenia at an accelerated rate resulting in structural changes potentially culminating in limb loss.
To review the evidence on methods of detecting and measuring sarcopenic changes on magnetic resonance imaging (MRI) in the foot in patients with diabetes.
A literature review was conducted in accordance with PRISMA guidelines. We searched Embase and Medline (via Ovid), CINAHL (via Ebsco Host), Web of Science and Scopus as well as the grey literature. The MeSH terms "sarcopenia" AND "diabetes mellitus" AND "magnetic resonance imaging" were employed in the primary search string.
874 studies were identified. 404 articles were excluded in the title and abstract screening. 33 studies were assessed for eligibility after abstract and title screening was completed by two reviewers. 7 studies evaluating sarcopenia in the foot were included in the final review.
Sarcopenic changes are evident on MRI of the foot in patients with diabetes and is profound in patients with diabetic neuropathy. The general extent and severity of sarcopenia seems to correlate with clinical scores to assess neuropathy and is implicated in the development of diabetic foot disease.
肌肉减少症的定义是肌肉量、质量指标较低且身体机能下降。它与更高程度的虚弱相关。糖尿病患者会加速出现肌肉减少症，导致结构变化，最终可能导致肢体丧失。
综述关于糖尿病患者足部磁共振成像（MRI）检测和测量肌肉减少症变化方法的证据。
按照PRISMA指南进行文献综述。我们检索了Embase和Medline（通过Ovid）、CINAHL（通过Ebsco Host）、科学网和Scopus以及灰色文献。在主要检索词中使用了医学主题词“肌肉减少症”、“糖尿病”和“磁共振成像”。
共识别出874项研究。在标题和摘要筛选中排除了404篇文章。在两名评审员完成标题和摘要筛选后，对33项研究进行了资格评估。最终综述纳入了7项评估足部肌肉减少症的研究。
糖尿病患者足部的MRI显示出明显的肌肉减少症变化，在糖尿病神经病变患者中更为严重。肌肉减少症的总体范围和严重程度似乎与评估神经病变的临床评分相关，并与糖尿病足病的发生有关。
