Wang Min, Zhou Qiyang, Guo Xinyu, Cui Xiaolong, Tang Zhongquan, Ou Ting, Zhao Xiaomin, Liang Chen, Xu Peiyu, Dai Xinyu, Yao Jingqing, Ji Guozhong, Li Yuntao
Department of General Practice, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Neurology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Front Med (Lausanne). 2025 May 27;12:1586308. doi: 10.3389/fmed.2025.1586308. eCollection 2025.
Diabetes mellitus and sarcopenia are chronic metabolic disorders characterized by bidirectional interactions, frequently coexisting as comorbidities whose interrelationship has garnered increasing scientific attention. This study pioneers a bibliometric analysis to systematically investigate their association, aiming to map the knowledge structure, evolutionary trajectories, current foci, and emerging frontiers within this area.
We retrieved 2,773 publications from the Web of Science Core Collection from inception until December 26, 2024, and visual analyses were conducted using CiteSpace, VOSviewer, R, and Microsoft Excel. The analysis characterized disciplinary distributions, publication outputs, national/regional contributions, institutional collaborations, authorship networks, journal profiles, references, and keywords.
Annual publications demonstrated sustained growth, with the United States dominating scholarly contributions. Research exhibited marked interdisciplinary integration, although investigations linking type 1 diabetes mellitus with sarcopenia remain limited. Current research hotspots included shared pathological mechanisms such as insulin resistance and chronic inflammation, clinical characterization of specific subtypes such as sarcopenic obesity, imaging-based assessment of muscle dysfunction in diabetes, and the therapeutic efficacy of exercise as an intervention. Mechanistic exploration was determined to be the primary driver of domain advancement.
The field has evolved from theoretical frameworks to clinical applications, highlighting the importance of uncovering common pathophysiological mechanisms and pinpointing potential therapeutic targets. Future priorities include refining screening and diagnostic protocols, optimizing preventive strategies, and developing personalized interventions. Cross-disciplinary innovations integrating multi-omics and precision medicine are poised to reshape this research landscape.
糖尿病和肌肉减少症是慢性代谢性疾病，其特征是存在双向相互作用，常作为合并症同时存在，它们之间的相互关系已引起越来越多的科学关注。本研究率先进行文献计量分析，以系统地研究它们之间的关联，旨在描绘该领域的知识结构、进化轨迹、当前焦点和新兴前沿。
我们从科学网核心合集检索了从创刊到2024年12月26日的2773篇出版物，并使用CiteSpace、VOSviewer、R和Microsoft Excel进行了可视化分析。该分析涵盖学科分布、出版物产出、国家/地区贡献、机构合作、作者网络、期刊概况、参考文献和关键词。
年度出版物数量持续增长，美国在学术贡献方面占据主导地位。研究显示出明显的跨学科整合，尽管将1型糖尿病与肌肉减少症联系起来的研究仍然有限。当前的研究热点包括胰岛素抵抗和慢性炎症等共同病理机制、肌肉减少性肥胖等特定亚型的临床特征、基于影像学的糖尿病肌肉功能障碍评估以及运动作为干预措施的治疗效果。机制探索被确定为该领域进展的主要驱动力。
该领域已从理论框架发展到临床应用，凸显了揭示共同病理生理机制和确定潜在治疗靶点的重要性。未来的重点包括完善筛查和诊断方案、优化预防策略以及开发个性化干预措施。整合多组学和精准医学的跨学科创新有望重塑这一研究格局。
