Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda.
Laboratory Department, Sebbi Hospital, P.O. Box 101602, Kampala, Uganda.
BMC Res Notes. 2024 Oct 24;17(1):321. doi: 10.1186/s13104-024-06973-8.
Candida africana is an emergent variant that has been listed as a new species or variety within the Candida albicans complex since 2001. It has a worldwide intra-albicans complex pooled prevalence of 1.67% and varies between 0 and 8% depending on geographical region. We present the results of a pilot study on its prevalence in Uganda.
We conducted a cross-sectional study between March and June 2023. We recruited 4 pregnant women from Mulago Specialized Women and Neonatal Hospital, 102 from Kawempe National Referral Hospital, and 48 from Sebbi Hospital. Vaginal swabs were tested using microscopy, culture and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF).
The prevalence of C. africana was zero. Out of the 103 isolates, the majority (81.553%) were identified as Candida albicans, followed by Nakeseomyces glabrata (13.592%) and Pichia kudriavzevii (1.942%). Cyberlindnera jadinii, Candida tropicalis, and Candida parapsilosis each accounted for 0.971% of the isolates.
The prevalence of C. africana in Uganda is zero. However, large-scale cross-sectional studies, including studies involving the collection of vaginal samples from both urban and rural settings in Uganda and the use of both MALDI-TOF- and PCR-based laboratory methods, are needed to fully describe the public health burden of C. africana infections.
非洲假丝酵母是一种新兴的变体，自 2001 年以来被列为白念珠菌复合体中的一个新物种或变种。它在白念珠菌复合体中的全球流行率为 1.67%，根据地理位置的不同，其流行率在 0 到 8%之间变化。我们报告了一项关于其在乌干达流行率的初步研究结果。
我们在 2023 年 3 月至 6 月期间进行了一项横断面研究。我们从穆拉戈专科医院招募了 4 名孕妇，从卡文佩国家转诊医院招募了 102 名孕妇，从塞比医院招募了 48 名孕妇。使用显微镜检查、培养和基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）对阴道拭子进行了检测。
C. africana 的流行率为零。在 103 株分离株中，大多数（81.553%）被鉴定为白念珠菌，其次是 Nakeseomyces glabrata（13.592%）和 Pichia kudriavzevii（1.942%）。Cyberlindnera jadinii、Candida tropicalis 和 Candida parapsilosis 分别占分离株的 0.971%。
C. africana 在乌干达的流行率为零。然而，需要进行大规模的横断面研究，包括在乌干达城乡地区收集阴道样本的研究，并使用 MALDI-TOF 和基于 PCR 的实验室方法，以充分描述 C. africana 感染的公共卫生负担。
