Carabetta Nicole, Siracusa Chiara, Leo Isabella, Panuccio Giuseppe, Strangio Antonio, Sabatino Jolanda, Torella Daniele, De Rosa Salvatore
Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
Noncoding RNA. 2024 Oct 23;10(6):53. doi: 10.3390/ncrna10060053.
Cardiomyopathies are the structural and functional disorders of the myocardium. Etiopathogenesis is complex and involves an interplay of genetic, environmental, and lifestyle factors eventually leading to myocardial abnormalities. It is known that non-coding (Nc) RNAs, including micro (mi)-RNAs and long non-coding (lnc) RNAs, play a crucial role in regulating gene expression. Several studies have explored the role of miRNAs in the development of various pathologies, including heart diseases. In this review, we analyzed various patterns of ncRNAs expressed in the most common cardiomyopathies: dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy. Understanding the role of different ncRNAs implicated in cardiomyopathic processes may contribute to the identification of potential therapeutic targets and novel risk stratification models based on gene expression. The analysis of ncRNAs may also be helpful to unveil the molecular mechanisms subtended to these diseases.
心肌病是心肌的结构和功能紊乱。病因发病机制复杂，涉及遗传、环境和生活方式因素的相互作用，最终导致心肌异常。已知非编码（Nc）RNA，包括微小（mi）RNA和长链非编码（lnc）RNA，在调节基因表达中起关键作用。多项研究探讨了miRNA在包括心脏病在内的各种病理过程发展中的作用。在本综述中，我们分析了在最常见的心肌病（扩张型心肌病、肥厚型心肌病和致心律失常性心肌病）中表达的各种ncRNA模式。了解参与心肌病过程的不同ncRNA的作用，可能有助于确定潜在的治疗靶点以及基于基因表达的新型风险分层模型。对ncRNA的分析也可能有助于揭示这些疾病背后的分子机制。
