Creswell Aaron, Connor Cortney M, Ko Raymond, Tu Sally, Karim Shahnawaz, Lui Forshing
Neurology, California Northstate University College of Medicine, Elk Grove, USA.
Neurology, Kaiser Permanente, Sacramento, USA.
Cureus. 2024 Sep 24;16(9):e70107. doi: 10.7759/cureus.70107. eCollection 2024 Sep.
West Nile virus (WNV) is the most common mosquito-borne illness in the United States. Most cases remain asymptomatic or may be associated with a mild febrile illness; however, it can invade the central nervous system and cause meningoencephalitis, or rarely, acute flaccid paralysis (AFP). Here, we describe a case of WNV-associated paralysis in a previously healthy male presenting with asymmetric weakness and absent deep tendon reflexes. Magnetic resonance imaging (MRI) of the spine displayed a hyperintensity lesion restricted to the central gray matter, preferentially affecting the ventral horns, which is reflected by his clinical features. This case contributes to mounting evidence that WNV can cause selective injury to the ventral gray matter of the spinal cord and demonstrates that WNV should be considered a unique causative agent in patients presenting with AFP.
西尼罗河病毒（WNV）是美国最常见的蚊媒疾病。大多数病例无症状或可能伴有轻度发热性疾病；然而，它可侵袭中枢神经系统并导致脑膜脑炎，或很少见的急性弛缓性麻痹（AFP）。在此，我们描述一例WNV相关麻痹病例，患者为一名既往健康男性，表现为不对称性肌无力和深部腱反射消失。脊柱磁共振成像（MRI）显示一个高强度病变，局限于中央灰质，优先影响腹侧角，这与他的临床特征相符。该病例进一步证明了WNV可导致脊髓腹侧灰质的选择性损伤，并表明在出现AFP的患者中，WNV应被视为一种独特的病原体。
