Johnstone Jennie, Hanna Steven E, Nicolle Lindsay E, Drebot Michael A, Neupane Binod, Mahony James B, Loeb Mark B
Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S-4K1, Canada.
J Med Case Rep. 2011 Aug 19;5:395. doi: 10.1186/1752-1947-5-395.
Little is known about the long-term health related quality of life outcomes in patients with West Nile virus associated acute flaccid paralysis. We describe the quality of life scores of seven patients with acute flaccid paralysis who presented to hospital between 2003 and 2006, and were followed for up to two years.
Between 2003 and 2006, 157 symptomatic patients with West Nile virus were enrolled in a longitudinal cohort study of West Nile virus in Canada. Seven patients (4%) had acute flaccid paralysis. The first patient was a 55-year-old man who presented with left upper extremity weakness. The second patient was a 54-year-old man who presented with bilateral upper extremity weakness. The third patient was a 66-year-old woman who developed bilateral upper and lower extremity weakness. The fourth patient was a 67-year-old man who presented with right lower extremity weakness. The fifth patient was a 60-year-old woman who developed bilateral lower extremity weakness. The sixth patient was a 71-year-old man with a history of Parkinson's disease and acute onset bilateral lower extremity weakness. The seventh patient was a 52-year-old man who presented with right lower extremity weakness. All were Caucasian. Patients were followed for a mean of 1.1 years. At the end of follow-up the mean score on the Physical Component Summary of the Short-Form 36 scale had only slightly increased to 39. In contrast, mean score on the Mental Component Summary of the Short-Form 36 scale at the end of follow-up had normalized to 50.
Despite the poor physical prognosis for patients with acute flaccid paralysis, the mental health outcomes are generally favorable.
西尼罗河病毒相关急性弛缓性麻痹患者的长期健康相关生活质量结局鲜为人知。我们描述了2003年至2006年间入院的7例急性弛缓性麻痹患者的生活质量评分，并对其进行了长达两年的随访。
2003年至2006年间，157例有症状的西尼罗河病毒患者被纳入加拿大一项西尼罗河病毒纵向队列研究。7例患者（4%）出现急性弛缓性麻痹。首例患者为一名55岁男性，表现为左上肢无力。第二例患者为一名54岁男性，表现为双侧上肢无力。第三例患者为一名66岁女性，出现双侧上下肢无力。第四例患者为一名67岁男性，表现为右下肢无力。第五例患者为一名60岁女性，出现双侧下肢无力。第六例患者为一名71岁男性，有帕金森病病史，急性起病双侧下肢无力。第七例患者为一名52岁男性，表现为右下肢无力。所有患者均为白种人。患者平均随访1.1年。随访结束时，简明健康状况调查量表36项身体成分总结量表的平均得分仅略有上升至39分。相比之下，随访结束时简明健康状况调查量表36项精神成分总结量表的平均得分已恢复正常至50分。
尽管急性弛缓性麻痹患者的身体预后较差，但心理健康结局总体良好。
