西尼罗河病毒（WNV）感染相关的伴有眼肌麻痹的急性弛缓性麻痹

West Nile Virus (WNV) Infection-Associated Acute Flaccid Paralysis With Ophthalmoplegia.

作者信息

Adidam Venkata Srikanth, Hakobyan Narek, Lerner David P, Sundar Ramaswami, Kay Arthur

机构信息

Internal Medicine, Brookdale University Hospital Medical Center, New York City, USA.

Neurology, Brookdale University Hospital Medical Center, New York City, USA.

出版信息

Cureus. 2023 Apr 26;15(4):e38137. doi: 10.7759/cureus.38137. eCollection 2023 Apr.

DOI:10.7759/cureus.38137

PMID:37252502

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10214308/

Abstract

Infection with West Nile virus (WNV) is often characterized by a mild febrile illness, but it can progress to meningitis, encephalitis, flaccid paralysis, and respiratory failure. The neuro-ophthalmological manifestations of this disease are uncommonly discussed. This case describes a 49-year-old undomiciled male who developed WNV flaccid paralysis with ophthalmoplegia. His symptoms began with difficulty in walking and progressed over several days to flaccid paralysis and ophthalmoplegia. Cerebrospinal fluid was positive for WNV immunoglobulin M antibodies and electromyography demonstrated acute denervation in several muscle groups. This is an unusual case of neuro-invasive WNV presenting with flaccid paralysis and ophthalmoplegia.

摘要

感染西尼罗河病毒（WNV）通常表现为轻度发热性疾病，但也可能进展为脑膜炎、脑炎、弛缓性麻痹和呼吸衰竭。这种疾病的神经眼科表现很少被讨论。本病例描述了一名49岁无固定住所的男性，他患上了伴有眼肌麻痹的西尼罗河病毒弛缓性麻痹。他的症状始于行走困难，并在数天内进展为弛缓性麻痹和眼肌麻痹。脑脊液西尼罗河病毒免疫球蛋白M抗体呈阳性，肌电图显示多个肌肉群出现急性去神经支配。这是一例罕见的神经侵袭性西尼罗河病毒病例，表现为弛缓性麻痹和眼肌麻痹。