Rathi Hinal, Patra Tumpa, Poojary Indira, Pathak Prutha R, Haley Heather
Internal Medicine, University of Alabama Heersink School of Medicine Huntsville Regional Campus, Huntsville, USA.
Internal Medicine, Crestwood Medical Center, Huntsville, USA.
Cureus. 2024 Sep 24;16(9):e70069. doi: 10.7759/cureus.70069. eCollection 2024 Sep.
Mixed cryoglobulinemia (MC) is commonly associated with chronic hepatitis C infection. Symptoms usually present as a clinical triad of purpuric rash, arthralgia, and generalized weakness. There have been several case reports establishing the relationship between hepatitis C and MC. Here, we report a case of a 22-year-old female presenting with bilateral lower extremity and facial swelling with no history of hepatitis C developing idiopathic mixed cryoglobulinemia. She was treated with intravenous steroids, rituximab, and plasmapheresis, resulting in improvement with outpatient nephrology and oncology follow-ups.
混合性冷球蛋白血症（MC）通常与慢性丙型肝炎感染相关。症状通常表现为紫癜性皮疹、关节痛和全身乏力的临床三联征。已有多篇病例报告证实丙型肝炎与MC之间的关系。在此，我们报告一例22岁女性，无丙型肝炎病史，出现双侧下肢和面部肿胀，诊断为特发性混合性冷球蛋白血症。她接受了静脉注射类固醇、利妥昔单抗和血浆置换治疗，在门诊肾病科和肿瘤科随访中病情有所改善。
