Yoneda Kazuhiro, Hosomi Sanae, Ito Hiroshi, Togami Yuki, Oda Sayaka, Matsumoto Hisatake, Shimazaki Junya, Ogura Hiroshi, Oda Jun
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Laboratory of Human Immunology (Single Cell Genomics), WPI Osaka University Immunology Research Center, Osaka University, Osaka, Japan.
Front Neurosci. 2024 Oct 10;18:1437216. doi: 10.3389/fnins.2024.1437216. eCollection 2024.
Record-breaking heat waves over the past 20 years have led to a global increase in heat-related deaths, including heatstroke. Heat-related illnesses occur when the body cannot adapt to the elevated temperatures in the environment, leading to various symptoms. In severe situations, such as heatstroke, the body temperature can rise above 40°C, leading to significant injury to body systems, with particular susceptibility of the central nervous system (CNS). Neuroimaging studies conducted months or years after a heatstroke have revealed cellular damage in the cerebellum and other brain regions, including the hippocampus, midbrain, and thalamus, with the potential for long-term neurological complications in survivors of a heatstroke. This mini review aimed to describe the mechanisms and pathways underlying the development of brain injury induced by heatstroke and identify diagnostic imaging tools and biomarkers for injury to the CNS due to a heatstroke.
在过去20年里，破纪录的热浪导致全球与高温相关的死亡人数增加，其中包括中暑死亡。当身体无法适应环境中升高的温度时，就会发生与高温相关的疾病，从而引发各种症状。在严重的情况下，如中暑，体温会升至40°C以上，导致身体系统受到严重损伤，中枢神经系统（CNS）尤其易受影响。在中暑数月或数年之后进行的神经影像学研究显示，小脑以及其他脑区（包括海马体、中脑和丘脑）存在细胞损伤，中暑幸存者有出现长期神经并发症的可能。这篇小型综述旨在描述中暑所致脑损伤的发生机制和途径，并确定用于诊断中暑所致中枢神经系统损伤的成像工具和生物标志物。
