Clinical Chemistry Department, Sudan University of Science and Technology,, Khartoum, Khartoum, 11111, Sudan.
Department of Parasitology and Medical Entomology, Sudan University of Science and Technology, Khartoum, Khartoum, 11111, Sudan.
F1000Res. 2024 Oct 7;11:472. doi: 10.12688/f1000research.110927.1. eCollection 2022.
Type 2 diabetes mellitus (T2DM) and its consequences are a serious global public health issue. By 2030, the number of people with type 2 diabetes is predicted to reach 439 million. The purpose of this study is to evaluate the plasma levels of glucose, HbA1c, insulin, and lipid profile in Sudanese T2DM patients. This case control study included 165 Sudanese patients with diabetic type 2 and a cardiovascular condition as cases and 165 diabetic type 2 volunteers without a cardiovascular disorder as controls. The concentrations of plasma glucose, HbA1c, and lipid profile were assessed using a Mindray BS-480 auto-chemistry analyzer, and insulin was analyzed using a Cobase 411 auto analyzer. The collected data were analyzed using statistical tools for social science computer programs (SPSS version 21). According to the findings, (59.4%) of patients between the ages of (50-69). Females made up 50.9%. (38.2%) of patients had an illness duration of between (8-15 years). (41.8%) of individuals did not have hypertension. There was a substantial rise in BMI, FBG, HbA1c, HDL-C, and insulin among diabetics with cardiovascular disease compared to diabetics without cardiovascular disease (p-value = 0.001, 0.000, 0.018, and 0.000). Females had significantly higher blood TC, LDL-C, HDL-C, and BMI than males (p-values = 0.000, 0,001, and 0.000, respectively). There were significant positive correlation between FBS, HBA1c, insulin and duration of disease (r=0.155, p, value=0.005) (r=0.160, p, value=0.004)(r=0.103, p. value=0.061)respectively, while there were significant negative correlation between TC, TG,LDL-C, HDL-C and duration of disease (r=-0.152, p, value= 0.006)(r=-0.023, p, value=0.678)(r=-0.113, p, value= 0.040)(r=-0.145, p, value=0.008)respectively. When comparing diabetics with cardiovascular disease to diabetics without cardiovascular disease, there was a substantial rise in BMI, FBG, HbA1c, HDL-C, and insulin. FBS, HBA1c, insulin, and illness duration all had a strong positive connection.
2 型糖尿病（T2DM）及其后果是一个严重的全球公共卫生问题。到 2030 年，预计 2 型糖尿病患者人数将达到 4.39 亿。本研究旨在评估苏丹 2 型糖尿病患者的血浆葡萄糖、HbA1c、胰岛素和血脂谱水平。这项病例对照研究包括 165 名患有 2 型糖尿病和心血管疾病的苏丹患者作为病例组，和 165 名患有 2 型糖尿病但没有心血管疾病的志愿者作为对照组。使用 Mindray BS-480 自动化学分析仪评估血浆葡萄糖、HbA1c 和血脂谱的浓度，使用 Cobase 411 自动分析仪分析胰岛素。使用社会科学计算机程序统计工具（SPSS 版本 21）分析收集的数据。根据研究结果，（59.4%）的患者年龄在（50-69）岁之间。女性占 50.9%。（38.2%）的患者疾病持续时间在（8-15）年之间。（41.8%）的个体没有高血压。与没有心血管疾病的糖尿病患者相比，患有心血管疾病的糖尿病患者的 BMI、FBG、HbA1c、HDL-C 和胰岛素显著升高（p 值=0.001、0.000、0.018 和 0.000）。女性的血液 TC、LDL-C、HDL-C 和 BMI 明显高于男性（p 值分别为 0.000、0、0.001 和 0.000）。FBS、HBA1c、胰岛素与疾病持续时间之间存在显著正相关（r=0.155，p 值=0.005）（r=0.160，p 值=0.004）（r=0.103，p 值=0.061），而 TC、TG、LDL-C 和 HDL-C 与疾病持续时间之间存在显著负相关（r=-0.152，p 值=0.006）（r=-0.023，p 值=0.678）（r=-0.113，p 值=0.040）（r=-0.145，p 值=0.008）。与没有心血管疾病的糖尿病患者相比，患有心血管疾病的糖尿病患者的 BMI、FBG、HbA1c、HDL-C 和胰岛素显著升高。FBS、HBA1c、胰岛素和疾病持续时间之间均存在较强的正相关关系。
