Uddin Mohammad Faisal, Garapati Anusha, Gyanendra K C, Vikram V C, Gangahar Ankur, Chowdary Nisha, Omira Abdullah, Syed Anwar, Khan Ayesha Abid, Mateen Mohammed Abdul, Orfali Hamza
Shadan Institute of Medical Sciences, Teaching Hospital and Research Centre Hyderabad India.
College of medical sciences Bharatpur Chaiwan Nepal.
Health Sci Rep. 2025 Jun 30;8(7):e70965. doi: 10.1002/hsr2.70965. eCollection 2025 Jul.
The chronic metabolic disorder type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia due to low insulin secretion and impaired insulin resistance. Dyslipidemia and cardiovascular diseases are commonly associated with T2DM. Glycated hemoglobin (HbA1c) is a potential marker for long-term glycemic control in T2DM, and many researchers have studied its relationship with serum lipid profiles. The objective of this study was to investigate the correlation between HbA1c and lipid parameters in T2DM patients at a tertiary care hospital to improve understanding and guide clinical management of such patients.
One hundred T2DM patients (53 females, 47 males) taking treatment at a tertiary care hospital in Hyderabad were included. The lipids parameters, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and very low-density lipoprotein cholesterol (VLDL) and HbA1c, as well as fasting plasma glucose (FPG), were collected from the existing records after taking necessary permissions. Pearson correlation coefficients and linear regression models were used to investigate the statistical correlation between HbA1c and lipid parameters. A -value below 0.05 was considered statistically significant.
The HbA1c values were significantly higher in females than in males ( = 0.008). The triglyceride levels were significantly higher in patients with poor glycemic control (157.50 ± 94.80 mg/dL) than those with good glycemic control (130.90 ± 69.50 mg/dL, = 0.025). A positive correlation was observed between HbA1c and triglycerides ( = 0.17, = 0.018), whereas no significant correlation was found between HbA1c and other lipid parameters.
This study highlights a statistically significant weak positive correlation between HbA1c and triglyceride levels in T2DM patients, emphasizing the importance of integrated glycemic and lipid control strategies to reduce cardiovascular risk. Glycemic control can enhance lipid profiles, specifically triglyceride levels, and reduce the risk of complications associated with diabetes.
慢性代谢性疾病2型糖尿病（T2DM）的特征是由于胰岛素分泌不足和胰岛素抵抗受损导致持续性高血糖。血脂异常和心血管疾病通常与T2DM相关。糖化血红蛋白（HbA1c）是T2DM长期血糖控制的一个潜在标志物，许多研究人员已对其与血清脂质谱的关系进行了研究。本研究的目的是调查一家三级医疗机构中T2DM患者的HbA1c与血脂参数之间的相关性，以增进对此类患者的了解并指导临床管理。
纳入在海得拉巴一家三级医疗机构接受治疗的100例T2DM患者（53例女性，47例男性）。在获得必要许可后，从现有记录中收集血脂参数，包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL）、极低密度脂蛋白胆固醇（VLDL）以及HbA1c，还有空腹血糖（FPG）。采用Pearson相关系数和线性回归模型来研究HbA1c与血脂参数之间的统计学相关性。P值低于0.05被认为具有统计学意义。
女性的HbA1c值显著高于男性（P = 0.008）。血糖控制不佳的患者甘油三酯水平（157.50±94.80mg/dL）显著高于血糖控制良好的患者（130.90±69.50mg/dL，P = 0.025）。观察到HbA1c与甘油三酯之间存在正相关（r = 0.17，P = 0.018），而HbA1c与其他血脂参数之间未发现显著相关性。
本研究突出了T2DM患者中HbA1c与甘油三酯水平之间存在统计学显著的弱正相关，强调了综合血糖和血脂控制策略对于降低心血管风险的重要性。血糖控制可改善血脂谱，特别是甘油三酯水平，并降低与糖尿病相关的并发症风险。
