• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种与LED-PIV系统集成的混合模拟循环回路，用于研究腹主动脉瘤顺应性模型。

A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms.

作者信息

Bardi Francesco, Gasparotti Emanuele, Vignali Emanuele, Antonuccio Maria Nicole, Storto Eleonora, Avril Stéphane, Celi Simona

机构信息

BioCardioLab, Bioengineering Unit, Ospedale del Cuore, Massa, Italy.

Mines Saint-Étienne, Université Jean Monnet, INSERM, Saint Étienne, France.

出版信息

Front Bioeng Biotechnol. 2024 Oct 10;12:1452278. doi: 10.3389/fbioe.2024.1452278. eCollection 2024.

DOI:10.3389/fbioe.2024.1452278
PMID:39450327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11499900/
Abstract

BACKGROUND

Cardiovascular diseases remain a leading cause of morbidity and mortality worldwide and require extensive investigation through studies. Mock Circulatory Loops (MCLs) are advanced platforms that accurately replicate physiological and pathological hemodynamic conditions, while also allowing for precise and patient-specific data collection. Particle Image Velocimetry (PIV) is the standard flow visualization technique for studies, but it is costly and requires strict safety measures. High-power Light Emitting Diode illuminated PIV (LED-PIV) offers a safer and cheaper alternative.

METHODS

In this study, we aim to demonstrate the feasibility of a Hybrid-MCL integrated with a LED-PIV system for the investigation of Abdominal Aortic Aneurysm (AAA) compliant phantoms. We considered two distinct AAA models, namely, an idealized model and a patient-specific one under different physiological flow and pressure conditions.

RESULTS

The efficacy of the proposed setup for the investigation of AAA hemodynamics was confirmed by observing velocity and vorticity fields across multiple flow rate scenarios and regions of interest.

CONCLUSION

The findings of this study underscore the potential impact of Hybrid-MCL integrated with a LED-PIV system on enhancing the affordability, accessibility, and safety of CVD investigations.

摘要

背景

心血管疾病仍然是全球发病和死亡的主要原因，需要通过研究进行广泛调查。模拟循环回路（MCLs）是先进的平台，能够准确复制生理和病理血流动力学状况，同时还能进行精确且针对患者的数据采集。粒子图像测速技术（PIV）是研究中的标准流动可视化技术，但成本高昂且需要严格的安全措施。高功率发光二极管照明的PIV（LED - PIV）提供了一种更安全、更便宜的替代方案。

方法

在本研究中，我们旨在证明将混合MCL与LED - PIV系统集成用于研究腹主动脉瘤（AAA）顺应性模型的可行性。我们考虑了两种不同的AAA模型，即理想化模型和在不同生理流量和压力条件下的患者特异性模型。

结果

通过观察多个流速场景和感兴趣区域的速度和涡度场，证实了所提出的用于研究AAA血流动力学设置的有效性。

结论

本研究结果强调了将混合MCL与LED - PIV系统集成对提高心血管疾病（CVD）研究的可承受性、可及性和安全性的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/8006f9e5f35a/fbioe-12-1452278-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/6b6172141753/fbioe-12-1452278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/30dd350bb823/fbioe-12-1452278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/cb2a8b16876f/fbioe-12-1452278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/5e9b9236e069/fbioe-12-1452278-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/25fa4a3e6068/fbioe-12-1452278-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/76ce192c5545/fbioe-12-1452278-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/0f5ab2491eb7/fbioe-12-1452278-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/04e801b005ab/fbioe-12-1452278-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/434ae0edb34b/fbioe-12-1452278-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/0d60bb4ac5a8/fbioe-12-1452278-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/ef5f76a783a5/fbioe-12-1452278-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/b31ea5799a5b/fbioe-12-1452278-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/8006f9e5f35a/fbioe-12-1452278-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/6b6172141753/fbioe-12-1452278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/30dd350bb823/fbioe-12-1452278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/cb2a8b16876f/fbioe-12-1452278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/5e9b9236e069/fbioe-12-1452278-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/25fa4a3e6068/fbioe-12-1452278-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/76ce192c5545/fbioe-12-1452278-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/0f5ab2491eb7/fbioe-12-1452278-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/04e801b005ab/fbioe-12-1452278-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/434ae0edb34b/fbioe-12-1452278-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/0d60bb4ac5a8/fbioe-12-1452278-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/ef5f76a783a5/fbioe-12-1452278-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/b31ea5799a5b/fbioe-12-1452278-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce31/11499900/8006f9e5f35a/fbioe-12-1452278-g013.jpg

相似文献

1
A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms.一种与LED-PIV系统集成的混合模拟循环回路，用于研究腹主动脉瘤顺应性模型。
Front Bioeng Biotechnol. 2024 Oct 10;12:1452278. doi: 10.3389/fbioe.2024.1452278. eCollection 2024.
2
Integrated particle image velocimetry and fluid-structure interaction analysis for patient-specific abdominal aortic aneurysm studies.针对特定患者的腹主动脉瘤研究的集成粒子图像测速和流固耦合分析。
Biomed Eng Online. 2023 Dec 3;22(1):113. doi: 10.1186/s12938-023-01179-8.
3
Effects of intraluminal thrombus on patient-specific abdominal aortic aneurysm hemodynamics via stereoscopic particle image velocity and computational fluid dynamics modeling.通过立体粒子图像测速技术和计算流体动力学建模研究腔内血栓对患者特异性腹主动脉瘤血流动力学的影响。
J Biomech Eng. 2014 Mar;136(3):031001. doi: 10.1115/1.4026160.
4
Evaluation of a Desktop 3D Printed Rigid Refractive-Indexed-Matched Flow Phantom for PIV Measurements on Cerebral Aneurysms.用于脑动脉瘤粒子图像测速测量的桌面式3D打印刚性折射率匹配流动体模的评估
Cardiovasc Eng Technol. 2020 Feb;11(1):14-23. doi: 10.1007/s13239-019-00444-z. Epub 2019 Dec 9.
5
Particle Image Velocimetry Investigation of Hemodynamics via Aortic Phantom.粒子图像测速术通过主动脉模型研究血液动力学。
J Vis Exp. 2022 Feb 25(180). doi: 10.3791/63492.
6
Development of a numerical pump testing framework.数值泵测试框架的开发。
Artif Organs. 2014 Sep;38(9):783-90. doi: 10.1111/aor.12395.
7
Use of 3D anatomical models in mock circulatory loops for cardiac medical device testing.三维解剖模型在模拟循环回路中用于心脏医疗设备测试的应用。
Artif Organs. 2023 Feb;47(2):260-272. doi: 10.1111/aor.14433. Epub 2022 Nov 12.
8
Smartphone-based particle image velocimetry for cardiovascular flows applications: A focus on coronary arteries.用于心血管血流应用的基于智能手机的粒子图像测速技术：聚焦于冠状动脉。
Front Bioeng Biotechnol. 2022 Dec 8;10:1011806. doi: 10.3389/fbioe.2022.1011806. eCollection 2022.
9
Development of a custom-designed echo particle image velocimetry system for multi-component hemodynamic measurements: system characterization and initial experimental results.用于多组分血流动力学测量的定制回声粒子图像测速系统的开发：系统特性及初步实验结果
Phys Med Biol. 2008 Mar 7;53(5):1397-412. doi: 10.1088/0031-9155/53/5/015. Epub 2008 Feb 14.
10
In vitro flow study in a compliant abdominal aorta phantom with a non-Newtonian blood-mimicking fluid.在具有非牛顿血液模拟液的顺应性腹主动脉体模中进行体外血流研究。
J Biomech. 2022 Jan;130:110899. doi: 10.1016/j.jbiomech.2021.110899. Epub 2021 Dec 7.

引用本文的文献

1
Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation, experiment, and deep learning.动脉瘤血流动力学分析的综合多学科方法：数值模拟、实验与深度学习
Front Bioeng Biotechnol. 2025 Jun 3;13:1602190. doi: 10.3389/fbioe.2025.1602190. eCollection 2025.

本文引用的文献

1
Smartphone-based particle tracking velocimetry for the in vitro assessment of coronary flows.基于智能手机的粒子跟踪测速法用于体外评估冠状动脉血流。
Med Eng Phys. 2024 Apr;126:104144. doi: 10.1016/j.medengphy.2024.104144. Epub 2024 Mar 11.
2
Review of Systemic Mock Circulation Loops for Evaluation of Implantable Cardiovascular Devices and Biological Tissues.用于评估植入式心血管装置和生物组织的系统性模拟循环回路综述
J Endovasc Ther. 2025 Oct;32(5):1278-1300. doi: 10.1177/15266028241235876. Epub 2024 Mar 25.
3
Fabrication of deformable patient-specific AAA models by material casting techniques.
通过材料铸造技术制造可变形的患者特异性腹主动脉瘤模型。
Front Cardiovasc Med. 2023 Sep 11;10:1141623. doi: 10.3389/fcvm.2023.1141623. eCollection 2023.
4
Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns.腹主动脉瘤壁的快速应变图谱显示出异质性模式。
Front Physiol. 2023 Jun 8;14:1163204. doi: 10.3389/fphys.2023.1163204. eCollection 2023.
5
Changes in Aortic Diameter and Wall Strain in Progressing Abdominal Aortic Aneurysms.进展性腹主动脉瘤的主动脉直径和壁应变变化。
J Ultrasound Med. 2023 Aug;42(8):1737-1746. doi: 10.1002/jum.16193. Epub 2023 Feb 16.
6
Smartphone-based particle image velocimetry for cardiovascular flows applications: A focus on coronary arteries.用于心血管血流应用的基于智能手机的粒子图像测速技术：聚焦于冠状动脉。
Front Bioeng Biotechnol. 2022 Dec 8;10:1011806. doi: 10.3389/fbioe.2022.1011806. eCollection 2022.
7
A Hybrid Mock Circulatory Loop for Fluid Dynamic Characterization of 3D Anatomical Phantoms.一种用于3D解剖模型流体动力学特性表征的混合模拟循环回路。
IEEE Trans Biomed Eng. 2023 May;70(5):1651-1661. doi: 10.1109/TBME.2022.3224581. Epub 2023 Apr 20.
8
High-Versatility Left Ventricle Pump and Aortic Mock Circulatory Loop Development for Patient-Specific Hemodynamic In Vitro Analysis.高通用性左心室泵和主动脉模拟循环回路的开发，用于患者特定的体外血液动力学分析。
ASAIO J. 2022 Oct 1;68(10):1272-1281. doi: 10.1097/MAT.0000000000001651. Epub 2022 Jan 12.
9
Particle Image Velocimetry to Evaluate Pulse Wave Velocity in Aorta Phantom with the lnD-U Method.粒子图像测速法评估 lnD-U 方法主动脉模型脉搏波速度。
Cardiovasc Eng Technol. 2023 Feb;14(1):141-151. doi: 10.1007/s13239-022-00642-2. Epub 2022 Sep 20.
10
Towards the 2D velocity reconstruction in abdominal aorta from Color-Doppler Ultrasound.关于从彩色多普勒超声进行腹主动脉二维速度重建的研究
Med Eng Phys. 2022 Sep;107:103873. doi: 10.1016/j.medengphy.2022.103873. Epub 2022 Aug 6.