Oni Toluwanimi M, Gamagedara Sanjeewa, Floyd Evan L
Department of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th Street, Oklahoma City, OK 73104, United States.
Department of Chemistry, University of Central Oklahoma, 100 N. University Dr., Edmond, OK 73034, United States.
Ann Work Expo Health. 2025 Jan 8;69(1):104-108. doi: 10.1093/annweh/wxae080.
Efficient sampling materials are essential for assessing nicotine levels in vape shops and other settings where nicotine exposures may exist. Two different treatments of Whatman glass fiber type A (GF/A) filters (sodium bisulfate treated and citric acid treated) were evaluated for nicotine capture, desorption efficiency, and holding capacity using Gas Chromatography-Mass Spectrometry (GC-MS). The Filters were treated with 0.8 mL of 0.1 M sodium bisulfate or citric acid solution and oven-dried (80 °C) for 30 min. Nicotine was desorbed off the filters using a modified analytical method. The average nicotine desorption efficiency for sodium bisulfate-treated GF/A filters (98.4%) was significantly higher than that of citric acid-treated GF/A filters (60.9%) over a range of 1-100 µg nicotine. Sodium bisulfate-treated and citric acid-treated GF/A filters experienced a 10% nicotine breakthrough after being dosed with about 550 and 2,750 µg of nicotine, respectively compared to 75 µg for untreated GF/A filters. Citric acid-treated GF/A filters had a much greater nicotine-holding capacity, but nicotine desorption from citric acid-treated GF/A filters was below the recommended criteria. Therefore, we recommend that sodium bisulfate-treated GF/A filters are employed for sample of nicotine with the GC-MS method.
高效的采样材料对于评估电子烟商店和其他可能存在尼古丁暴露的场所中的尼古丁水平至关重要。使用气相色谱-质谱联用仪（GC-MS）对两种不同处理的沃特曼A型玻璃纤维（GF/A）滤膜（硫酸氢钠处理和柠檬酸处理）进行了尼古丁捕获、解吸效率和保留容量评估。滤膜用0.8 mL 0.1 M硫酸氢钠或柠檬酸溶液处理，并在烘箱中于80°C干燥30分钟。使用改良的分析方法从滤膜上解吸出尼古丁。在1-100μg尼古丁范围内，硫酸氢钠处理的GF/A滤膜的平均尼古丁解吸效率（98.4%）显著高于柠檬酸处理的GF/A滤膜（60.9%）。硫酸氢钠处理的和柠檬酸处理的GF/A滤膜在分别加入约550μg和2750μg尼古丁后出现了10%的尼古丁穿透，而未处理的GF/A滤膜为75μg。柠檬酸处理的GF/A滤膜具有更大的尼古丁保留容量，但柠檬酸处理的GF/A滤膜的尼古丁解吸低于推荐标准。因此，我们建议采用硫酸氢钠处理的GF/A滤膜通过GC-MS方法进行尼古丁采样。
