过氧化物酶体增殖物激活受体在免疫介导的肠道疾病中的多功能作用。
The Versatile Role of Peroxisome Proliferator-Activated Receptors in Immune-Mediated Intestinal Diseases.
机构信息
GI Unit, Department of Infectology, Faculty of Medicine, University of Debrecen, Bartok Bela Street 2-26, 4031 Debrecen, Hungary.
Institute of Food Technology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Böszörményi út 138, 4032 Debrecen, Hungary.
出版信息
Cells. 2024 Oct 12;13(20):1688. doi: 10.3390/cells13201688.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that sense lipophilic molecules and act as transcription factors to regulate target genes. PPARs have been implicated in the regulation of innate immunity, glucose and lipid metabolism, cell proliferation, wound healing, and fibrotic processes. Some synthetic PPAR ligands are promising molecules for the treatment of inflammatory and fibrotic processes in immune-mediated intestinal diseases. Some of these are currently undergoing or have previously undergone clinical trials. Dietary PPAR ligands and changes in microbiota composition could modulate PPARs' activation to reduce inflammatory responses in these immune-mediated diseases, based on animal models and clinical trials. This narrative review aims to summarize the role of PPARs in immune-mediated bowel diseases and their potential therapeutic use.
过氧化物酶体增殖物激活受体 (PPARs) 是一种核受体，能够感知亲脂性分子，并作为转录因子调节靶基因。PPARs 参与调节先天免疫、葡萄糖和脂质代谢、细胞增殖、伤口愈合和纤维化过程。一些合成的 PPAR 配体是治疗免疫介导的肠道疾病中炎症和纤维化过程的有前途的分子。其中一些目前正在进行或以前已经进行过临床试验。基于动物模型和临床试验，膳食 PPAR 配体和微生物群落组成的变化可以调节 PPAR 的激活，以减少这些免疫介导的疾病中的炎症反应。本综述旨在总结 PPARs 在免疫介导的肠道疾病中的作用及其潜在的治疗用途。
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