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通过基于壳聚糖的水凝胶的动态设计来调节抗氧化功能。

Tuning Antioxidant Function through Dynamic Design of Chitosan-Based Hydrogels.

作者信息

Iftime Manuela Maria, Ailiesei Gabriela Liliana, Ailincai Daniela

机构信息

"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, 700487 Iasi, Romania.

The Research Institute of the University of Bucharest (ICUB), 90 Sos. Panduri, 050663 Bucharest, Romania.

出版信息

Gels. 2024 Oct 13;10(10):655. doi: 10.3390/gels10100655.

DOI:10.3390/gels10100655
PMID:39451308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11507920/
Abstract

Dynamic chitosan-based hydrogels with enhanced antioxidant activity were synthesized through the formation of reversible imine linkages with 5-methoxy-salicylaldehyde. These hydrogels exhibited a porous structure and swelling capacity, influenced by the crosslinking degree, as confirmed by SEM and POM analysis. The dynamic nature of the imine bonds was characterized through NMR, swelling studies in various media, and aldehyde release measurements. The hydrogels demonstrated significantly improved antioxidant activity compared to unmodified chitosan, as evaluated by the DPPH method. This research highlights the potential of developing pH-responsive chitosan-based hydrogels for a wide range of biomedical applications.

摘要

通过与5-甲氧基水杨醛形成可逆亚胺键，合成了具有增强抗氧化活性的动态壳聚糖基水凝胶。扫描电子显微镜（SEM）和偏光显微镜（POM）分析证实，这些水凝胶呈现出多孔结构和溶胀能力，且受交联度影响。通过核磁共振（NMR）、在各种介质中的溶胀研究以及醛释放测量对亚胺键的动态性质进行了表征。通过DPPH法评估，与未改性的壳聚糖相比，该水凝胶表现出显著提高的抗氧化活性。这项研究突出了开发用于广泛生物医学应用的pH响应性壳聚糖基水凝胶的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/47829228030e/gels-10-00655-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/711c8f41b7fc/gels-10-00655-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/d5264be8eeaf/gels-10-00655-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/093f14819bd9/gels-10-00655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/25105ddea4e3/gels-10-00655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/cfd228d5305e/gels-10-00655-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/d2b2cbd615e4/gels-10-00655-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/6ddcd821d1fd/gels-10-00655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/4bfa72deeba6/gels-10-00655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/115aec952729/gels-10-00655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/25c863cb3f5b/gels-10-00655-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/bb96554732fe/gels-10-00655-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/47829228030e/gels-10-00655-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/711c8f41b7fc/gels-10-00655-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/d5264be8eeaf/gels-10-00655-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/093f14819bd9/gels-10-00655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/25105ddea4e3/gels-10-00655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/cfd228d5305e/gels-10-00655-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/d2b2cbd615e4/gels-10-00655-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/6ddcd821d1fd/gels-10-00655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/4bfa72deeba6/gels-10-00655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/115aec952729/gels-10-00655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/25c863cb3f5b/gels-10-00655-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/bb96554732fe/gels-10-00655-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/104f/11507920/47829228030e/gels-10-00655-g009.jpg

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Effect of Chitosan and Its Water-Soluble Derivatives on Antioxidant Activity.壳聚糖及其水溶性衍生物对抗氧化活性的影响。
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Preparation, physicochemical characterization and swelling properties of composite hydrogel microparticles based on gelatin and pectins with different structure.基于不同结构的明胶和果胶的复合水凝胶微球的制备、理化特性及溶胀性能。
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