Gao Shuang, Wang Yu, Huang Ming, Guo Jianxin, Wu Zhongbing, Li Jing
College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Institute of Integrated Traditional Chinese and Western Medicine, Hebei Medical University, Shijiazhuang 050017, China.
Curr Issues Mol Biol. 2024 Oct 13;46(10):11349-11358. doi: 10.3390/cimb46100676.
Esophageal squamous cell carcinoma (ESCC) is a malignant tumor of the digestive tract with strong migratory and invasive abilities. Gas6 is closely associated with the progression of many malignant tumors; however, the role of Gas6 in the progression of esophageal cancer is unclear. Here, we report that the knockdown of Gas6 inhibited esophageal cancer cell proliferation, migration, and invasion. In addition, Gas6 knockdown downregulated the levels of P-PI3K and P-AKT. Taken together, the findings confirm that Gas6 knockdown can inhibit esophageal cancer progression and can exert anti-tumor effects on esophageal cancer through the PI3K/AKT pathway.
食管鳞状细胞癌（ESCC）是一种具有较强迁移和侵袭能力的消化道恶性肿瘤。Gas6与许多恶性肿瘤的进展密切相关；然而，Gas6在食管癌进展中的作用尚不清楚。在此，我们报告Gas6基因敲低可抑制食管癌细胞的增殖、迁移和侵袭。此外，Gas6基因敲低下调了P-PI3K和P-AKT的水平。综上所述，这些发现证实Gas6基因敲低可抑制食管癌进展，并可通过PI3K/AKT途径对食管癌发挥抗肿瘤作用。
