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一名儿科患者的罕见支气管内肿瘤。

A Rare Endobronchial Tumor in a Pediatric Patient.

作者信息

Parekh Pooja, Wagh Ajay

机构信息

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Division of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

出版信息

Diagnostics (Basel). 2024 Oct 10;14(20):2254. doi: 10.3390/diagnostics14202254.

DOI:10.3390/diagnostics14202254
PMID:39451577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11506295/
Abstract

A pediatric patient who presented with non-specific respiratory symptoms, including mild hemoptysis, wheezing, and eventual respiratory distress, was found to have a rare endobronchial inflammatory myofibroblastic tumor obstructing her right mainstem bronchus. It was diagnosed and initially debulked using bronchoscopy, which helped to stabilize the patient and eliminate the need for supplemental oxygen. The patient subsequently underwent successful removal of the residual tumor with parenchymal-sparing sleeve resection. This case highlights the importance of pursuing appropriate imaging along with diagnostic and therapeutic bronchoscopy for an endobronchial lesion to help manage pediatric patients with persistent respiratory symptoms.

摘要

一名儿科患者出现非特异性呼吸道症状,包括轻度咯血、喘息,最终出现呼吸窘迫,经检查发现患有罕见的支气管内炎性肌纤维母细胞瘤,阻塞了她的右主支气管。通过支气管镜检查进行了诊断并初步切除肿瘤,这有助于稳定患者病情并消除对补充氧气的需求。该患者随后通过保留实质组织的袖状切除术成功切除了残留肿瘤。这个病例强调了对于支气管内病变,进行适当的影像学检查以及诊断性和治疗性支气管镜检查对于管理有持续呼吸道症状的儿科患者的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/b2cb91d38053/diagnostics-14-02254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/1a72c978c1a7/diagnostics-14-02254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/388c907c76b0/diagnostics-14-02254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/b2cb91d38053/diagnostics-14-02254-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/1a72c978c1a7/diagnostics-14-02254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/388c907c76b0/diagnostics-14-02254-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c0c/11506295/b2cb91d38053/diagnostics-14-02254-g003.jpg

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A Rare Endobronchial Tumor in a Pediatric Patient.一名儿科患者的罕见支气管内肿瘤。
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本文引用的文献

1
Inflammatory Myofibroblastic Tumour: State of the Art.炎性肌纤维母细胞瘤:最新进展
Cancers (Basel). 2022 Jul 27;14(15):3662. doi: 10.3390/cancers14153662.
2
Treatment of Pediatric Inflammatory Myofibroblastic Tumor: The Experience from China Children's Medical Center.儿童炎性肌纤维母细胞瘤的治疗:来自中国儿童医学中心的经验
Children (Basel). 2022 Feb 24;9(3):307. doi: 10.3390/children9030307.
3
Long-term efficacy update of crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumour from EORTC trial 90101 CREATE.
来自欧洲癌症研究与治疗组织(EORTC)90101 CREATE试验的克唑替尼治疗晚期不可切除炎性肌纤维母细胞瘤患者的长期疗效更新
Eur J Cancer. 2021 Oct;156:12-23. doi: 10.1016/j.ejca.2021.07.016. Epub 2021 Aug 13.
4
Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis.中央气道炎性肌纤维母细胞瘤:治疗与分子分析
ERJ Open Res. 2021 Mar 22;7(1). doi: 10.1183/23120541.00151-2020. eCollection 2021 Jan.
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Tracheal and bronchial tumors.气管和支气管肿瘤。
J Thorac Dis. 2016 Dec;8(12):3781-3786. doi: 10.21037/jtd.2016.12.67.
6
Bronchoscopic debulking for endobronchial malignancy: Predictors of recanalization and recurrence.支气管镜下切除术治疗支气管内恶性肿瘤:再通和复发的预测因素。
Thorac Cancer. 2015 Nov;6(6):722-30. doi: 10.1111/1759-7714.12248. Epub 2015 Mar 16.
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Characteristics of endobronchial primitive tumors in children.儿童支气管内原发性肿瘤的特征
Pediatr Pulmonol. 2014 Jun;49(6):E121-5. doi: 10.1002/ppul.22987. Epub 2014 Feb 16.
8
Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases.炎性肌成纤维细胞瘤:非典型及侵袭性病例的临床病理、组织学和免疫组化特征比较,包括ALK表达情况
Am J Surg Pathol. 2007 Apr;31(4):509-20. doi: 10.1097/01.pas.0000213393.57322.c7.