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颅咽管瘤和成釉细胞瘤的比较免疫组织化学分析：对牙源性分化的见解

Comparative Immunohistochemical Analysis of Craniopharyngioma and Ameloblastoma: Insights into Odontogenic Differentiation.

作者信息

Salih Ban A, Abdullah Bashar H

机构信息

College of Dentistry, University of Baghdad, Baghdad 10071, Iraq.

出版信息

Diagnostics (Basel). 2024 Oct 17;14(20):2315. doi: 10.3390/diagnostics14202315.

DOI:10.3390/diagnostics14202315
PMID:39451638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11506693/
Abstract

BACKGROUND AND OBJECTIVES

Histopathological similarities between craniopharyngioma (CP) and ameloblastoma (AB) have long been recognized, particularly the shared features of palisading columnar epithelium and stellate reticulum-like areas. This study aimed to investigate potential odontogenic differentiation in CP akin to AB using immunohistochemical odontogenic markers.

METHODS

We analyzed AMELX, ODAM, and CK19 expression in 44 cases (20 CP and 24 AB).

RESULTS

While AMELX and ODAM showed diffuse strong positive expression in both tumors with no significant statistical differences, CK19 expression was notably higher in CP.

CONCLUSION

The markers AMELX and ODAM associated with odontogenic differentiation exhibited similar profiles in both tumors due to shared similar embryological origins. Notably, CK19, a biomarker of odontogenic epithelium, showed even higher expression, suggesting distinct pathways. These findings offer insights into tumor biology and may aid in diagnostic and therapeutic approaches.

摘要

背景与目的

颅咽管瘤（CP）和成釉细胞瘤（AB）之间的组织病理学相似性早已为人所知，尤其是栅栏状柱状上皮和星网状样区域的共同特征。本研究旨在使用免疫组化牙源性标志物调查CP中类似于AB的潜在牙源性分化。

方法

我们分析了44例病例（20例CP和24例AB）中AMELX、ODAM和CK19的表达。

结果

虽然AMELX和ODAM在两种肿瘤中均呈弥漫性强阳性表达，无显著统计学差异，但CP中CK19的表达明显更高。

结论

由于胚胎学起源相似，与牙源性分化相关的标志物AMELX和ODAM在两种肿瘤中表现出相似的特征。值得注意的是，牙源性上皮的生物标志物CK19表达甚至更高，提示存在不同的途径。这些发现为肿瘤生物学提供了见解，并可能有助于诊断和治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/19538d0aea82/diagnostics-14-02315-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/3808585f897a/diagnostics-14-02315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/e4b3ddd49d68/diagnostics-14-02315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/acbf4579b589/diagnostics-14-02315-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/2c18d99d908c/diagnostics-14-02315-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/19538d0aea82/diagnostics-14-02315-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/3808585f897a/diagnostics-14-02315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/e4b3ddd49d68/diagnostics-14-02315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/acbf4579b589/diagnostics-14-02315-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/2c18d99d908c/diagnostics-14-02315-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2743/11506693/19538d0aea82/diagnostics-14-02315-g005.jpg

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Arch Endocrinol Metab. 2023 Mar 10;67(2):266-275. doi: 10.20945/2359-3997000000600. Epub 2023 Feb 7.
2
Correlation of amyloid and ameloblast-associated proteins to odontogenic cysts and tumors: A cross-sectional study.淀粉样蛋白和成釉细胞相关蛋白与牙源性囊肿和肿瘤的相关性：一项横断面研究。
Health Sci Rep. 2023 Jan 12;6(1):e1061. doi: 10.1002/hsr2.1061. eCollection 2023 Jan.
3
Clinical, Radiographic and Histopathological Analysis of Craniopharyngiomas and Ameloblastomas: A Systematic Review.
颅咽管瘤和造釉细胞瘤的临床、影像学和组织病理学分析：系统评价。
Head Neck Pathol. 2022 Dec;16(4):1195-1222. doi: 10.1007/s12105-022-01473-2. Epub 2022 Aug 3.
4
Clinical significance of cytokeratin 19 and OCT4 as survival markers in non-metastatic and metastatic breast cancer patients.细胞角蛋白19和OCT4作为非转移性和转移性乳腺癌患者生存标志物的临床意义
Contemp Oncol (Pozn). 2022;26(1):78-87. doi: 10.5114/wo.2022.115678. Epub 2022 Mar 30.
5
Expression of stem cell marker cytokeratin 19 in reduced enamel epithelium, dentigerous cyst and unicystic ameloblastoma - A comparative analysis.干细胞标志物细胞角蛋白19在缩余釉上皮、含牙囊肿及单囊型成釉细胞瘤中的表达——一项对比分析。
J Oral Maxillofac Pathol. 2021 Jan-Apr;25(1):136-140. doi: 10.4103/jomfp.JOMFP_316_19. Epub 2021 May 14.
6
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7
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J Periodontal Res. 2021 Jun;56(3):482-491. doi: 10.1111/jre.12848. Epub 2021 Jan 16.
8
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J Biol Chem. 2020 Feb 14;295(7):1943-1959. doi: 10.1074/jbc.RA119.010506. Epub 2020 Jan 9.
9
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10
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J Cell Physiol. 2019 Dec;234(12):21425-21435. doi: 10.1002/jcp.28768. Epub 2019 May 1.