Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Postgraduate Program in Dental Sciences, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Head Neck Pathol. 2022 Dec;16(4):1195-1222. doi: 10.1007/s12105-022-01473-2. Epub 2022 Aug 3.
Craniopharyngiomas and ameloblastomas are tumors of epithelial origin, mostly characterized by a benign course, slow growth and for being locally invasive. Some studies highlight the similarity of these neoplasms, especially regarding histopathological aspects. In this context, the aim of the present study was to carry out a systematic literature review correlating the clinical, radiographic, and histopathological aspects of these two tumors.
Searches were conducted at the Pubmed, Periódicos Capes, Scopus, Science Direct, Web of Science and Scielo databases, according to the following inclusion criteria: publications in English or Spanish, from the 2000s and 2021, comprising case report studies, case series and literature reviews.
Considering clinical and radiographic aspects, it is evident that craniopharyngiomas and ameloblastomas exhibit few similarities. Histopathologically, however, adamantinomatous craniopharyngiomas are the type of tumor that most resembles ameloblastomas, both concerning the formation of palisade epithelial cords and epithelial formations. Regarding to recurrences in cases of craniopharyngioma, it appears that a more radical surgical resection is more related to a lower recurrence rate for both craniopharyngiomas and ameloblastomas. As for the outcome, it was observed that craniopharyngiomas have a greater relationship with possible systemic disorders.
This histopathological similarity is related to their origin, since both craniopharyngiomas and ameloblastomas share a relationship with the oral cavity, either partially, as in the case of craniopharyngiomas, or totally, as in ameloblastomas, not comprising the same lesion in different locations. It is important to note that the differential morphogenetic evidence observed herein between these lesions opens up a new field of study aiming at better treatment alternatives in the future.
颅咽管瘤和造釉细胞瘤是上皮来源的肿瘤，主要表现为良性病程、生长缓慢且具有局部侵袭性。一些研究强调了这些肿瘤的相似性，尤其是在组织病理学方面。在这种情况下，本研究的目的是对这两种肿瘤的临床、放射学和组织病理学方面进行系统的文献回顾。
根据以下纳入标准，在 Pubmed、Periódicos Capes、Scopus、Science Direct、Web of Science 和 Scielo 数据库中进行了检索：发表在英语或西班牙语的文献，来自 21 世纪 00 年代和 2021 年，包括病例报告研究、病例系列和文献综述。
考虑到临床和放射学方面，颅咽管瘤和造釉细胞瘤之间几乎没有相似之处。然而，在组织病理学方面，造釉细胞瘤中出现的牙釉质细胞瘤类型与造釉细胞瘤最为相似，这两种肿瘤都与栅栏状上皮索和上皮形成有关。关于颅咽管瘤的复发，似乎更彻底的手术切除与颅咽管瘤和造釉细胞瘤的较低复发率有关。至于结果，观察到颅咽管瘤与可能的全身疾病有更大的关系。
这种组织病理学上的相似性与其起源有关，因为颅咽管瘤和造釉细胞瘤都与口腔有一定的关系，要么像颅咽管瘤那样部分相关，要么像造釉细胞瘤那样完全相关，不在不同部位形成相同的病变。值得注意的是，在此观察到的这些病变之间的形态发生差异证据开辟了一个新的研究领域，旨在为未来提供更好的治疗选择。
