Department of Neurology and Wilhelm Sander-NeuroOncology Unit, Regensburg University Hospital, 93053 Regensburg, Germany.
Center for Quality Assurance and Health Services Research, University of Regensburg, 93053 Regensburg, Germany.
Curr Oncol. 2024 Oct 14;31(10):6155-6170. doi: 10.3390/curroncol31100459.
(1) Background: Clinical aspects like sex, age, Karnofsky Performance Scale (KPS) and psychosocial distress can affect the health-related quality of life (HR-QoL) and treatment satisfaction of patients with malignant isocitrate dehydrogenase wild-type (IDHwt) gliomas and caregivers. (2) Methods: We prospectively investigated the HR-QoL and patient/caregiver treatment satisfaction in a cross-sectional study with univariable and multiple regression analyses. Questionnaires were applied to investigate the HR-QoL (EORTC QLQ-C30, QLQ-BN20) and treatment satisfaction (EORTC PATSAT-C33). (3) Results: A cohort of 61 patients was investigated. A higher KPS was significantly associated with a better HR-QoL regarding the functional scales of the EORTC QLQ-C30 ( < 0.004) and a lower symptom burden regarding the EORTC QLQ-BN20 ( < 0.001). The patient treatment satisfaction was significantly poorer in the patients older than 60 years in the domain of family involvement ( = 0.010). None of the investigated aspects showed a significant impact on the treatment satisfaction of caregivers. (4) Conclusions: We demonstrated that in patients with IDHwt gliomas, the KPS was the most important predictor for a better HR-QoL in functional domains. Data on the HR-QoL and treatment satisfaction in patients with IDHwt gliomas and their caregivers are rare; therefore, further efforts should be made to improve supportive care in this highly distressed cohort.
（1）背景：性别、年龄、卡氏功能状态量表（KPS）和心理社会困扰等临床方面会影响恶性异柠檬酸脱氢酶野生型（IDHwt）胶质瘤患者及其照顾者的健康相关生活质量（HR-QoL）和治疗满意度。（2）方法：我们通过单变量和多变量回归分析，前瞻性地调查了横断面研究中的 HR-QoL 和患者/照顾者的治疗满意度。采用问卷调查来调查 HR-QoL（EORTC QLQ-C30、QLQ-BN20）和治疗满意度（EORTC PATSAT-C33）。（3）结果：共调查了 61 例患者。KPS 较高与 EORTC QLQ-C30 的功能量表（<0.004）和 EORTC QLQ-BN20 的症状负担（<0.001）较好相关。年龄大于 60 岁的患者在家庭参与方面的治疗满意度显著降低（=0.010）。在所调查的各方面中，均未发现对照顾者治疗满意度有显著影响。（4）结论：我们表明，在 IDHwt 胶质瘤患者中，KPS 是功能领域更好的 HR-QoL 的最重要预测因素。IDHwt 胶质瘤患者及其照顾者的 HR-QoL 和治疗满意度数据较为罕见；因此，应进一步努力改善这一高度困扰患者群体的支持性护理。
