Schut Anne-Rose W, Lidington Emma, Timbergen Milea J M, Younger Eugenie, van der Graaf Winette T A, van Houdt Winan J, Bonenkamp Johannes J, Jones Robin L, Grünhagen Dirk J, Sleijfer Stefan, Verhoef Cornelis, Gennatas Spyridon, Husson Olga
Department of Medical Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands.
Department of Surgical Oncology, Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands.
Cancers (Basel). 2022 Jun 16;14(12):2979. doi: 10.3390/cancers14122979.
Desmoid-type fibromatosis (DTF) is a rare, soft-tissue tumour. These tumours do not metastasize, but their local aggressive tumour growth and unpredictable behaviour can have a significant impact on health-related quality of life (HRQoL). Little is known about which DTF patients are particularly affected by an impaired HRQoL. The objectives of this study were to assess HRQoL among different groups of DTF patients and to investigate which socio-demographic and clinical characteristics were associated with DTF-specific HRQoL. A cross-sectional study was conducted among DTF patients from the United Kingdom and the Netherlands. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), accompanied by the DTF-QoL to assess DTF-specific HRQoL. The scores were compared amongst subgroups, based on the socio-demographic and clinical characteristics of DTF patients. Multiple linear regression analyses with a backward elimination were conducted to identify the factors associated with DTF-specific HRQoL. A total of 235 DTF patients completed the questionnaires. Female patients, patients with more than two comorbidities, or patients who received treatment other than only active surveillance (AS) or surgery scored significantly worse on the subscales of both the EORTC QLQ-C30 and DTF-QoL. Patients that were ≥ 40 years scored significantly worse on the physical functioning scale of the EORTC QLQ-C30, while younger patients (18-39 years) scored significantly worse on several DTF-QoL subscales. Differences in the DTF-QoL subscales were found for tumour location, time since diagnosis and the presence of recurrent disease. Furthermore, treatments other than AS or surgery only, female sex, younger age and the presence of comorbidities were most frequently associated with worse scores on the DTF-QoL subscales. This study showed that (DTF-specific) HRQoL differs between groups of DTF patients. Awareness of these HRQoL differences could help to provide better, personalised care that is tailored to the needs of a specific subgroup.
韧带样型纤维瘤病（DTF）是一种罕见的软组织肿瘤。这些肿瘤不会发生转移，但其局部侵袭性生长和不可预测的行为会对健康相关生活质量（HRQoL）产生重大影响。对于哪些DTF患者特别受HRQoL受损的影响，人们知之甚少。本研究的目的是评估不同组DTF患者的HRQoL，并调查哪些社会人口统计学和临床特征与DTF特异性HRQoL相关。对来自英国和荷兰的DTF患者进行了一项横断面研究。使用欧洲癌症研究与治疗组织生活质量问卷核心30（EORTC QLQ-C30）评估HRQoL，并辅以DTF-QoL来评估DTF特异性HRQoL。根据DTF患者的社会人口统计学和临床特征，在亚组之间比较得分。进行了带有向后消除法的多元线性回归分析，以确定与DTF特异性HRQoL相关的因素。共有235名DTF患者完成了问卷调查。女性患者、有两种以上合并症的患者，或接受了除主动监测（AS）或手术以外其他治疗的患者，在EORTC QLQ-C30和DTF-QoL的子量表上得分明显更差。年龄≥40岁的患者在EORTC QLQ-C30的身体功能量表上得分明显更差，而年轻患者（18 - 39岁）在几个DTF-QoL子量表上得分明显更差。在DTF-QoL子量表上发现了肿瘤位置、诊断后时间和复发性疾病的存在方面的差异。此外，除AS或仅手术以外的其他治疗、女性性别、年轻年龄和合并症的存在最常与DTF-QoL子量表上更差的得分相关。本研究表明，DTF患者组之间的（DTF特异性）HRQoL存在差异。认识到这些HRQoL差异有助于提供更好的、针对特定亚组需求的个性化护理。
