Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, 4031 Basel, Switzerland.
University Medical Library, University of Basel, 4031 Basel, Switzerland.
Curr Oncol. 2024 Oct 18;31(10):6300-6313. doi: 10.3390/curroncol31100470.
Patient-reported outcome measures (PROMs) have gained increased importance in assessing outcomes after reconstructive surgery. This also applies to the reconstruction of vulvoperineal defects after resection of gynecological or colorectal cancers in women. The objective of this study is to analyze the current state of PROM tool use within this patient population.
By systematic literature searches in Embase, Medline, and Web of Science, English-language studies published after 1980, including randomized controlled trials, cohort studies, and case series reporting on vulvoperineal defect reconstruction, which were included if they also analyzed quality of life (QoL) and/or PROMs. The PROM tools used by each study were extracted, analyzed, and compared.
The primary search yielded 2576 abstracts, of which 395 articles were retrieved in full text. Of these, 50 reported on vulvoperineal defect reconstruction, among which 27 studies analyzing QoL were found. Of those, 17 met the inclusion criteria for this systematic review. After full-text screening, 14 different PROM tools and 5 individual, non-standardized questionnaires were identified. Only 22% of studies used a validated PROM tool.
Far too few studies currently use PROM tools to assess outcomes in oncological vulvoperineal defect reconstruction. Less than half of the used PROMs are validated. No PROM was designed to specifically measure QoL in this patient population. The standardized implementation of a validated PROM tool in the clinical treatment of this patient population is an essential step to improve outcomes, enable the comparison of research, and support evidence-based treatment approaches.
患者报告的结果测量（PROMs）在评估重建手术后的结果方面变得越来越重要。这也适用于女性妇科或结直肠癌症切除后外阴会阴缺陷的重建。本研究的目的是分析当前该患者人群中使用 PROM 工具的情况。
通过在 Embase、Medline 和 Web of Science 中进行系统文献检索，检索 1980 年后发表的英语语言研究，包括随机对照试验、队列研究和病例系列报告，这些研究报告了外阴会阴缺陷重建，并分析了生活质量（QoL）和/或 PROMs。提取、分析和比较每个研究中使用的 PROM 工具。
初步搜索产生了 2576 篇摘要，其中 395 篇文章全文检索。其中，50 篇报道了外阴会阴缺陷重建，其中发现 27 项研究分析了 QoL。其中，17 项符合本系统评价的纳入标准。经过全文筛选，确定了 14 种不同的 PROM 工具和 5 种非标准化的问卷。只有 22%的研究使用了经过验证的 PROM 工具。
目前，很少有研究使用 PROM 工具来评估肿瘤外阴会阴缺陷重建的结果。使用的 PROM 中只有不到一半是经过验证的。没有专门为评估该患者人群的 QoL 而设计的 PROM。在该患者人群的临床治疗中标准化实施经过验证的 PROM 工具是改善结果、实现研究比较和支持循证治疗方法的重要步骤。
