Radu Andrei-Flavius, Bungau Simona Gabriela, Corb Aron Raluca Anca, Tarce Alexandra Georgiana, Bodog Ruxandra, Bodog Teodora Maria, Radu Ada
Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Antibiotics (Basel). 2024 Oct 5;13(10):938. doi: 10.3390/antibiotics13100938.
Drug interactions are a significant and integral part of the concept of medication-related adverse events, whether referring to potential interactions or those currently observed in real-world conditions. The high global consumption of antibiotics and their pharmacokinetic and pharmacodynamic mechanisms make antibiotic-drug interactions a key element that requires continuous study due to their clinical relevance. In the present work, the current state of knowledge on antibiotic-drug interactions, which are less studied than other drug-drug interactions despite their frequent use in acute settings, has been consolidated and updated. The focus was on the interactions of the commonly used antibiotics in clinical practice, on the characteristics of the geriatric population susceptible to interactions, and on the impact of online drug interaction checkers. Additionally, strategies for optimizing the management of these interactions, including spacing out administrations, monitoring, or avoiding certain combinations, are suggested. Sustained research and careful monitoring are critical for improving antibiotic safety and efficacy, especially in susceptible populations, to enhance precision in managing antibiotic-drug interactions.
药物相互作用是药物相关不良事件概念的重要组成部分，无论是指潜在的相互作用还是当前在实际临床中观察到的相互作用。抗生素在全球的高消耗量及其药代动力学和药效学机制，使得抗生素与其他药物之间的相互作用成为一个关键因素，鉴于其临床相关性，需要持续进行研究。在本研究中，尽管抗生素在急性病治疗中频繁使用，但与其他药物相互作用相比，抗生素与药物相互作用的研究较少，目前已对这方面的现有知识进行了整合和更新。重点关注临床实践中常用抗生素的相互作用、易发生相互作用的老年人群体的特征以及在线药物相互作用检查工具的影响。此外，还提出了优化这些相互作用管理的策略，包括错开给药时间、监测或避免某些药物组合。持续的研究和仔细的监测对于提高抗生素的安全性和有效性至关重要，特别是在易感人群中，以提高管理抗生素与药物相互作用的精准度。
