Golli Andreea-Loredana, Popa Simona Georgiana, Cara Monica Laura, Stoica George-Alin, Fortofoiu Dragos, Stoica Maria
Department of Public Health and Management, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Diabetes, Nutrition and Metabolic Diseases, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Antibiotics (Basel). 2024 Oct 13;13(10):966. doi: 10.3390/antibiotics13100966.
: The present study aims to highlight the possible significant changes due to the COVID-19 pandemic in the resistance of pathogens involved in cases of pediatric infections. : This study included children hospitalized in the Pediatric Intensive Care Unit, Surgery and Pediatrics from a tertiary teaching hospital, during and after the COVID-19 period (2020-2023). : The research included 845 samples collected during 2020-2023, from 685 pediatric patients. A total of 937 bacterial isolates were obtained, of which 509 isolates (54.32%) were Gram-negative bacteria. Around 30% of all the pathogens were multidrug-resistant (MDR), with a statistically significant increase post-pandemic, in the case of the MDR strains ( < 0.05). A very high percentage of MDR spp. isolates was found, with an important, but not statistically significant, increase in the post-pandemic period. The highest percentage of the MDR Gram-positive pathogens was registered in the case of strains (31.80%). Over 20% of the strains isolated between 2020 and 2023 were MDR, with an important increase in the post-COVID-19 period. The proportion of carbapenem-resistant Gram-negative pathogens significantly decreased in the post-COVID-19 period compared with the COVID-19 period ( < 0.05), especially in the case of the spp. strains. : Our findings revealed the increase in the post-COVID-19 period of the prevalence of MDR strains of spp., , and isolated in pediatric patient samples and a significant decline in the trend of the carbapenem-resistant Gram-negative pathogens, which may be due to the testing rate and to the specific pathology of the pediatric patients hospitalized in the two periods.
本研究旨在突出2019冠状病毒病大流行可能导致的小儿感染病例中所涉及病原体耐药性的显著变化。本研究纳入了一家三级教学医院在2019冠状病毒病期间及之后（2020 - 2023年）入住儿科重症监护病房、外科和儿科的儿童。该研究包括在2020 - 2023年期间从685名儿科患者中采集的845份样本。共获得937株细菌分离株，其中509株（54.32%）为革兰氏阴性菌。所有病原体中约30%为多重耐药菌（MDR），在大流行后多重耐药菌株的情况有统计学显著增加（P < 0.05）。发现了非常高比例的MDR spp.分离株，在大流行后时期有重要但无统计学显著意义的增加。MDR革兰氏阳性病原体的最高比例出现在 菌株中（31.80%）。2020年至2023年分离出的 菌株中超过20%为MDR，在2019冠状病毒病后时期有重要增加。与2019冠状病毒病时期相比，2019冠状病毒病后时期碳青霉烯耐药革兰氏阴性病原体的比例显著下降（P < 0.05），尤其是在 spp.菌株的情况下。我们的研究结果显示，在2019冠状病毒病后时期，儿科患者样本中分离出的 spp.、 和 的MDR菌株患病率增加，而碳青霉烯耐药革兰氏阴性病原体的趋势显著下降，这可能归因于检测率以及两个时期住院儿科患者的特定病理情况。
