Prajescu Bianca, Gavriliu Liana, Iesanu Mara Ioana, Ioan Andreea, Boboc Anca Andreea, Boboc Catalin, Galos Felicia
Department of Pediatrics, Marie Curie Emergency Children's Hospital, 041451 Bucharest, Romania.
Department for Prevention of Healthcare-Associated Infections, Marie Curie Emergency Children's Hospital, 041451 Bucharest, Romania.
Antibiotics (Basel). 2023 May 26;12(6):966. doi: 10.3390/antibiotics12060966.
Antimicrobial resistance (AMR) has become a major healthcare concern having a rising incidence, especially in pediatric patients who are more susceptible to infections. The aim of our study was to analyze the bacterial species isolated from patients admitted to our tertiary hospital and their AMR profiles. We conducted a retrospective observational study by examining the bacterial cultures collected from pediatric patients admitted to our hospital over a period of one year. We identified the most common bacterial species from 1445 clinical isolates and their AMR patterns using standard microbiological techniques. Our analysis revealed that the most frequently isolated bacterial species were (23.73%), (15.64%), (12.04%), and (9.96%). Additionally, these species exhibited varying levels of resistance to commonly used antibiotics. Notably, we observed high rates of resistance among Gram-negative bacteria, including extended-spectrum beta-lactamase-producing and . Among Gram-positive bacteria, we observed a high level of methicillin-resistant . Our findings highlight the urgent need for effective antibiotic management programs and infection control measures to address the rising incidence of AMR in pediatric hospitals. Further research is needed to identify the mechanisms of resistance in these bacterial species and to develop new strategies for preventing and treating infections caused by antibiotic-resistant bacteria in pediatric patients.
抗菌药物耐药性（AMR）已成为一个主要的医疗保健问题，其发病率不断上升，尤其是在更容易感染的儿科患者中。我们研究的目的是分析从我们三级医院收治的患者中分离出的细菌种类及其AMR谱。我们通过检查在一年时间内从我院收治的儿科患者中收集的细菌培养物进行了一项回顾性观察研究。我们使用标准微生物技术从1445份临床分离株中鉴定出最常见的细菌种类及其AMR模式。我们的分析表明，最常分离出的细菌种类为[具体细菌名称1]（23.73%）、[具体细菌名称2]（15.64%）、[具体细菌名称3]（12.04%）和[具体细菌名称4]（9.96%）。此外，这些菌种对常用抗生素表现出不同程度的耐药性。值得注意的是，我们观察到革兰氏阴性菌的耐药率很高，包括产超广谱β-内酰胺酶的[具体细菌名称5]和[具体细菌名称6]。在革兰氏阳性菌中，我们观察到耐甲氧西林的[具体细菌名称7]水平很高。我们的研究结果突出表明，迫切需要有效的抗生素管理计划和感染控制措施，以应对儿科医院中AMR发病率的上升。需要进一步研究以确定这些细菌种类的耐药机制，并制定预防和治疗儿科患者中由耐药菌引起的感染的新策略。
