Suslov Andrey V, Kirichenko Tatiana V, Omelchenko Andrey V, Chumachenko Petr V, Ivanova Alexandra, Zharikov Yury, Markina Yuliya V, Markin Alexander M, Postnov Anton Yu
Petrovsky National Research Center of Surgery, Moscow 119991, Russia.
Chazov National Medical Research Center of Cardiology, Moscow 121552, Russia.
J Cardiovasc Dev Dis. 2024 Oct 8;11(10):311. doi: 10.3390/jcdd11100311.
Thoracic aortic aneurysm is a latent disease with a high risk of death. Today, as data are accumulating, an estimation of the differences in thoracic aneurysm in men and women of different age groups is required. The present study evaluated the type of atherosclerotic aortic lesions in males and females at different ages regarding the presence or absence of aortic dissection.
A retrospective analysis of clinical and morphological data of 43 patients with thoracic aortic aneurysm was carried out. Patients were divided into groups based on the presence or absence of thoracic aneurysm dissection.
Our results of a comparative analysis of the age of study participants showed that patients with aneurysm dissection were younger than patients without dissection. In the subgroup of patients with aortic dissection, the mean age was 50.6 years old, and in patients without aortic dissection, the mean age was 55.0 years old. When conducting a frequency analysis using Fisher's exact test, it was found that in men and women aneurysm dissection was not associated with atherosclerotic lesions of the aorta.
In women and men, aneurysm dissection was not associated with stage of atherosclerotic lesions of the aorta regardless of age; no statistically significant differences were found between the groups with and without aneurysm dissection ( > 0.05). Dissection of the thoracic aneurysm developed in the absence of severe atherosclerosis of the thoracic aorta. Only 18.6% men and women possessed atherosclerotic plaques of types IV and V.
胸主动脉瘤是一种具有高死亡风险的潜在疾病。如今，随着数据的积累，需要对不同年龄组男性和女性胸主动脉瘤的差异进行评估。本研究评估了不同年龄男性和女性动脉粥样硬化性主动脉病变的类型，以及是否存在主动脉夹层。
对43例胸主动脉瘤患者的临床和形态学数据进行回顾性分析。根据是否存在胸主动脉瘤夹层将患者分组。
我们对研究参与者年龄的比较分析结果显示，有夹层的患者比无夹层的患者年轻。在主动脉夹层患者亚组中，平均年龄为50.6岁，无主动脉夹层患者的平均年龄为55.0岁。当使用Fisher精确检验进行频率分析时，发现男性和女性的动脉瘤夹层与主动脉粥样硬化病变无关。
无论年龄大小，男性和女性的动脉瘤夹层均与主动脉粥样硬化病变阶段无关；有和无动脉瘤夹层的组间未发现统计学显著差异（>0.05）。胸主动脉瘤夹层在胸主动脉无严重动脉粥样硬化的情况下发生。只有18.6%的男性和女性有IV型和V型动脉粥样硬化斑块。
