关于绝经前后女性阴道给予醋酸生育酚的回顾性研究者发起试验
Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women.
作者信息
Venditti Noemi, Petronio Petronio Giulio, Guarnieri Antonio, Pietrangelo Laura, Spicciato Angela, Colalillo Alessio, Sabusco Giovanna Paola, Barattini Dionisio Franco, Di Franco Aldo, Papini Stefano, Cosentino Francesco, Di Marco Roberto
机构信息
Department of Medicina e Scienze della Salute "V. Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.
UO Laboratorio Analisi, Responsible Research Hospital, 86100 Campobasso, Italy.
出版信息
Diseases. 2024 Oct 2;12(10):237. doi: 10.3390/diseases12100237.
BACKGROUND
Menopause, a natural phase in a woman's life, often adversely affects physical, mental, sexual, and emotional well-being due to low estrogen levels. This study examines the impact of vaginal ovules with tocopherol acetate (Filme Gyno-V ovules, manufactured by Panin Srl and distributed by Hulka Srl, Italy), 500 mg per ovule, on vaginal health in pre- and menopausal women.
METHODS
Fifty women aged 50-70 were divided into menopausal (28) and premenopausal (22) cohorts and treated with the ovules for two weeks, with assessments before and after treatment.
RESULTS
The findings showed that distressing symptoms of vaginal atrophy, such as dryness, itching, and pain during intercourse, were resolved post-treatment. A molecular analysis revealed a reduction in in both cohorts and an increase in three species of in premenopausal patients.
CONCLUSIONS
This study concludes that Filme Gyno-V ovules may benefit vaginal health by alleviating atrophy symptoms and promoting healthy vaginal microbiota.
背景
更年期是女性生命中的一个自然阶段，由于雌激素水平低，常常对身体、心理、性和情绪健康产生不利影响。本研究考察了每粒含500毫克醋酸生育酚的阴道栓剂（Filme Gyno-V栓剂，由意大利帕宁股份公司生产，胡尔卡股份公司经销）对绝经前和绝经后女性阴道健康的影响。
方法
50名年龄在50至70岁的女性被分为绝经组（28名）和绝经前组（22名），接受栓剂治疗两周，并在治疗前后进行评估。
结果
研究结果表明，阴道萎缩的令人苦恼的症状，如干燥、瘙痒和性交疼痛，在治疗后得到缓解。分子分析显示，两组中[此处原文缺失相关内容]均减少，绝经前患者中有三种[此处原文缺失相关内容]增加。
结论
本研究得出结论，Filme Gyno-V栓剂可能通过减轻萎缩症状和促进健康的阴道微生物群而有益于阴道健康。
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