Chandramohan Deepak, Singh Prabhat, Garapati Hari Naga, Konda Raghunandan, Chandramohan Divya, Jena Nihar, Bali Atul, Simhadri Prathap Kumar
Department of Internal Medicine/Nephrology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Department of Nephrology, Christus Spohn Hospital, Corpus Christi, TX 78404, USA.
Diseases. 2024 Oct 10;12(10):247. doi: 10.3390/diseases12100247.
Renal insufficiency is a risk factor for cardiac implantable electronic device (CIED) infection. : A comprehensive search was conducted from multiple electronic databases to identify studies. Using the random effects model, we calculated the pooled rates of CIED infection and their 95% confidence intervals. We also calculated the pooled odds ratios to determine the risk of CIED infections due to chronic kidney disease (CKD) and end-stage renal disease (ESRD). We utilized the Cochran Q and I2 statistics to detect and quantify heterogeneity. : A total of 17 studies comprising 359,784 patients with renal insufficiency were added to the meta-analysis. Out of these, 263,819 were CKD patients and 89,617 were ESRD patients. The pooled rate of CIED infection in patients with CKD was 4.3% (95% CI: 2-8.8; I2: 95.7), and in patients with ESRD, it was 4.8% (95% CI: 2.6-8.7; I2: 99.4). The pooled risk of CIED infection in the CKD population was OR 2.5 (95% CI: 1.9-3.3; < 0.001; I2: 21.1), and in the ESRD population, it was OR 2.4 (95% CI: 1.01-5.7; = 0.046; I2: 88.8). ESRD was associated with higher mortality, OR 2.5 (95% CI: 1.4-4.4.8; = 0.001; I2: 95). : The presence of renal insufficiency increases the number of CIED infections. In particular, patients with ESRD have an increased risk of mortality.
肾功能不全是心脏植入式电子设备（CIED）感染的一个危险因素。通过对多个电子数据库进行全面检索以识别相关研究。使用随机效应模型，我们计算了CIED感染的合并发生率及其95%置信区间。我们还计算了合并比值比，以确定慢性肾脏病（CKD）和终末期肾病（ESRD）导致CIED感染的风险。我们利用Cochran Q和I²统计量来检测和量化异质性。共有17项研究纳入荟萃分析，涉及359784例肾功能不全患者。其中，263819例为CKD患者，89617例为ESRD患者。CKD患者中CIED感染的合并发生率为4.3%（95%置信区间：2 - 8.8；I²：95.7），ESRD患者中为4.8%（95%置信区间：2.6 - 8.7；I²：99.4）。CKD人群中CIED感染的合并风险为OR 2.5（95%置信区间：1.9 - 3.3；P < 0.001；I²：21.1），ESRD人群中为OR 2.4（95%置信区间：1.01 - 5.7；P = 0.046；I²：88.8）。ESRD与更高的死亡率相关，OR 2.5（95%置信区间：1.4 - 4.4.8；P = 0.001；I²：95）。肾功能不全的存在会增加CIED感染的数量。特别是，ESRD患者的死亡风险增加。
