Trejo-Trejo Marina, Gómez-Miranda Luis M, Ramos-Jiménez Arnulfo
Sports Faculty, Autonomous University of Baja California, Mexicali 21289, Baja California, Mexico.
Department of Health Sciences, Biomedical Sciences Institute, Autonomous University of Ciudad Juarez, Chihuahua 32310, Chihuahua, Mexico.
Diseases. 2024 Oct 11;12(10):249. doi: 10.3390/diseases12100249.
No consensus exists on whether acute aerobic exercise alters the glomerular filtration rate in older adults.
To assess the immediate effects of three aerobic exercise intensities on the estimated glomerular filtration rate (eGFR) in healthy, sedentary older adults.
Eighteen healthy, sedentary older adults (ten men and eight women) voluntarily participated in this study. The participants underwent three standardized aerobic exercise tests (100%, 80%, and 60% of the maximal heart rate) on a bicycle ergometer. Blood samples were collected to determine cholesterol, triacylglycerols, glucose, serum creatinine (Cr), Cystatin C (CysC) concentrations, and eGFR.
eGFR and serum concentrations of Cr and CysC were not modified at any exercise intensity. There was a negative correlation between blood total cholesterol vs. eGFR (R = -0.512, R = -0.582, R = -0.531; < 0.05) at rest, 60%, and 100% of the maximal heart rate, respectively. In addition, a negative correlation existed for age vs. eGFR at 60% of the maximal heart rate (R = -0.516; < 0.05).
Short-duration aerobic exercise of low, moderate, and vigorous intensity did not significantly affect eGFR and is considered safe for kidney function in healthy, sedentary older adults. However, regular monitoring of kidney function in older people engaged in moderate- and high-intensity exercise is advised.
关于急性有氧运动是否会改变老年人的肾小球滤过率，目前尚无共识。
评估三种有氧运动强度对健康、久坐不动的老年人估计肾小球滤过率（eGFR）的即时影响。
18名健康、久坐不动的老年人（10名男性和8名女性）自愿参与本研究。参与者在自行车测力计上进行了三项标准化有氧运动测试（最大心率的100%、80%和60%）。采集血样以测定胆固醇、三酰甘油、葡萄糖、血清肌酐（Cr）、胱抑素C（CysC）浓度和eGFR。
在任何运动强度下，eGFR以及Cr和CysC的血清浓度均未改变。在静息状态、最大心率的60%和100%时，血总胆固醇与eGFR之间分别存在负相关（R = -0.512，R = -0.582，R = -0.531；P < 0.05）。此外，在最大心率的60%时，年龄与eGFR之间存在负相关（R = -0.516；P < 0.05）。
低、中、高强度的短时间有氧运动对eGFR无显著影响，对健康、久坐不动的老年人的肾功能而言被认为是安全的。然而，建议对进行中等强度和高强度运动的老年人定期监测肾功能。
