van Agtmaal Julia L, van Hoogstraten Sanne W G, Arts Jacobus J C
Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Care and Public Health Research Institute (CAPHRI), Maastricht University Medical Centre, 6229 Maastricht, The Netherlands.
Department of Biomedical Engineering, Orthopaedic Biomechanics, Eindhoven University of Technology, 5612 Eindhoven, The Netherlands.
J Funct Biomater. 2024 Oct 15;15(10):307. doi: 10.3390/jfb15100307.
Prosthetic joint infection (PJI) is a major complication following total arthroplasty. Rising antimicrobial resistance (AMR) to antibiotics will further increase therapeutic insufficiency. New antibacterial technologies are being developed to prevent PJI. In vivo models are still needed to bridge the translational gap to clinical implementation. Though rabbit models have been used most frequently, there is no consensus about methodology and measured outcomes. The PubMed, Scopus, and EMBASE databases were searched for literature on PJI in rabbit models. Data extraction included bias control, experimental design, and outcome measures of the NZW rabbit models in the articles. A total of 60 articles were included in this systematic literature review. The articles were divided into six groups based on the PJI intervention: no intervention used (21%), revision surgery (14%), prevention with only antibiotics (21%), prevention with surface modifications (7%), prevention with coatings (23%), and others (14%). Despite the current availability of guidelines and recommendations regarding experimental design, bias control, and outcome measures, many articles neglect to report on these matters. Ultimately, this analysis aims to assist researchers in determining suitable clinically relevant methodologies and outcome measures for in vivo PJI models using NZW rabbits to test new antimicrobial technologies.
人工关节感染（PJI）是全关节置换术后的一种主要并发症。抗生素耐药性（AMR）不断上升将进一步加剧治疗不足的情况。新型抗菌技术正在研发中，以预防PJI。仍需要体内模型来填补向临床应用转化的空白。虽然兔模型使用最为频繁，但在方法和测量结果方面尚无共识。检索了PubMed、Scopus和EMBASE数据库中有关兔模型PJI的文献。数据提取包括文章中新西兰白兔模型的偏倚控制、实验设计和结果测量。本系统文献综述共纳入60篇文章。根据PJI干预措施，这些文章分为六组：未采取干预措施（21%）、翻修手术（14%）、仅用抗生素预防（21%）、表面改性预防（7%）、涂层预防（23%）以及其他（14%）。尽管目前已有关于实验设计、偏倚控制和结果测量的指南与建议，但许多文章仍未报告这些内容。最终，本分析旨在帮助研究人员确定合适的、与临床相关的方法和结果测量指标，用于使用新西兰白兔的体内PJI模型来测试新型抗菌技术。
