Xu Yangqi, Huang Tony B, Schuetz Michael A, Choong Peter F M
Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia.
Jamieson Trauma Institute, Metro North Hospital and Health Service, Queensland Health, Brisbane, Queensland, Australia.
EFORT Open Rev. 2023 Sep 1;8(9):690-697. doi: 10.1530/EOR-23-0078.
Prosthetic joint infection (PJI) is one of the most devastating complications for a patient following arthroplasty. This scoping review aims to evaluate the burden of PJI on individual patients and the healthcare system regarding the mortality rate, patient-reported quality of life, and healthcare resource utilisation. Patients with PJI have up to a five-fold higher mortality rate than those who have undergone an uninfected primary arthroplasty. There is an increased use of ambulatory aids and reduced joint function scores in patients with PJI. Global quality of life is poorer, specifically measured by the EQ-5D. Direct hospitalisation costs are two- to five-fold higher, attributed to surgery and prostheses, antibiotics, and a prolonged inpatient stay. There is an immense clinical and health economic burden secondary to PJI worldwide. This is expected to rise exponentially due to the increasing number of primary procedures and an ageing population with comorbidities Improving preventative and treatment strategies is imperative for patients and the healthcare system.
人工关节感染（PJI）是关节置换术后患者面临的最具破坏性的并发症之一。本综述旨在评估PJI对个体患者和医疗系统在死亡率、患者报告的生活质量以及医疗资源利用方面的负担。患有PJI的患者的死亡率比接受未感染初次关节置换术的患者高出五倍。PJI患者使用辅助行走器具的频率增加，关节功能评分降低。总体生活质量较差，特别是通过EQ-5D测量。由于手术和假体、抗生素以及住院时间延长，直接住院费用高出两到五倍。在全球范围内，PJI会带来巨大的临床和健康经济负担。由于初次手术数量的增加以及患有合并症的老年人口的增加，预计这一负担将呈指数级上升。改善预防和治疗策略对患者和医疗系统来说势在必行。
