Biała Martyna, Mączyńska Beata, Starzyński Konrad, Rurańska-Smutnicka Danuta, Secewicz Anna, Szuba Paulina, Szetela Bartosz
Department of Infectious Diseases, Liver Diseases and Acquired Immune Deficiences, Wroclaw Medical University, 51-149 Wroclaw, Poland.
Department of Pharmaceutical Microbiology and Parasitology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Pathogens. 2024 Oct 11;13(10):890. doi: 10.3390/pathogens13100890.
(NG) has developed resistance to nearly all antibiotics used for its treatment. However, very limited data are available regarding the antimicrobial resistance of NG isolates among MSM in Poland. The aim of this study was to evaluate the susceptibility of isolates in this key population. We investigated the antimicrobial susceptibility of NG isolates to six antimicrobials (ceftriaxone, cefixime, azithromycin, ciprofloxacin, tetracycline, and benzylpenicillin). Minimum inhibitory concentrations (MICs; mg/L) were determined using Etests on gonococcal isolates. One hundred high-risk MSM were included in the study (25 HIV-positive and 75 HIV-negative using pre-exposure prophylaxis for HIV). The rate of NG infection was 28%. All NG isolates were susceptible to cefixime and ceftriaxone. Susceptibility to azithromycin was found in 69.2% (18/26) of the NG isolates and resistance in 30.8% (8/26) of NG isolates. Susceptibility to tetracycline was found in 50% (13/26) of the isolates and resistance in 50% (13/26) of the isolates. We observed gonorrhea to be more prevalent in patients with a higher number of oral sexual contacts. Increasing azithromycin resistance is especially concerning for future treatment options, especially if ceftriaxone/cefixime resistance starts to develop and for people with beta-lactam antibiotics allergies. Doxy-PEP might lose its partial efficacy for NG soon.
淋球菌（NG）已对几乎所有用于其治疗的抗生素产生耐药性。然而，关于波兰男男性行为者（MSM）中NG分离株的抗菌药物耐药性的数据非常有限。本研究的目的是评估这一关键人群中分离株的药敏情况。我们调查了NG分离株对六种抗菌药物（头孢曲松、头孢克肟、阿奇霉素、环丙沙星、四环素和苄星青霉素）的药敏情况。使用Etest法测定淋球菌分离株的最低抑菌浓度（MICs；mg/L）。100名高危男男性行为者纳入研究（25名HIV阳性，75名HIV阴性且正在使用HIV暴露前预防药物）。NG感染率为28%。所有NG分离株对头孢克肟和头孢曲松敏感。69.2%（18/26）的NG分离株对阿奇霉素敏感，30.8%（8/26）的NG分离株耐药。50%（13/26）的分离株对四环素敏感，50%（13/26）的分离株耐药。我们观察到口交接触次数较多的患者中淋病更为普遍。阿奇霉素耐药性增加对于未来的治疗选择尤其令人担忧，特别是如果头孢曲松/头孢克肟耐药性开始出现，以及对于对β-内酰胺类抗生素过敏的人群。多西环素暴露前预防（Doxy-PEP）可能很快会失去其对NG的部分疗效。
