Schwarzenbach Heidi
Department of Gynecology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Noncoding RNA. 2024 Sep 30;10(5):51. doi: 10.3390/ncrna10050051.
Epithelial ovarian cancer (EOC) with its high death incidence rate is generally detected at advanced stages. During its progression, EOC often develops peritoneal metastasis aggravating the outcomes of EOC patients. Studies on non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and circular RNAs (circRNAs), have analyzed the impact of miRNAs and circRNAs, along with their interaction among each other, on cancer cells. MiRNAs can act as oncogenes or tumor suppressors modulating post-transcriptional gene expression. There is accumulating evidence that circRNAs apply their stable, covalently closed, continuous circular structures to competitively inhibit miRNA function, and so act as competing endogenous RNAs (ceRNAs). This interplay between both ncRNAs participates in the malignity of a variety of cancer types, including EOC. In the current review, I describe the characteristics of miRNAs and circRNAs, and discuss their interplay with each other in the development, progression, and drug resistance of EOC. Sponging of miRNAs by circRNAs may be used as a biomarker and therapeutic target in EOC.
上皮性卵巢癌（EOC）死亡率高，通常在晚期才被发现。在其进展过程中，EOC常发生腹膜转移，加重患者预后。对非编码RNA（ncRNAs）的研究，如微小RNA（miRNAs）和环状RNA（circRNAs），分析了miRNAs和circRNAs及其相互作用对癌细胞的影响。miRNAs可作为癌基因或肿瘤抑制因子调节转录后基因表达。越来越多的证据表明，circRNAs利用其稳定的、共价闭合的连续环状结构竞争性抑制miRNA功能，从而作为竞争性内源RNA（ceRNAs）发挥作用。这两种ncRNAs之间的相互作用参与了包括EOC在内的多种癌症类型的恶性进展。在本综述中，我描述了miRNAs和circRNAs的特征，并讨论了它们在EOC的发生、发展和耐药性中的相互作用。circRNAs对miRNAs的海绵吸附作用可能作为EOC的生物标志物和治疗靶点。
