黑加仑花青素通过调节围绝经期和绝经后早期女性体内微生物衍生的短链羧酸和植物雌激素代谢产物，减轻雌激素缺乏引起的骨质流失。

Blackcurrant Anthocyanins Attenuate Estrogen -Deficiency-Induced Bone Loss through Modulating Microbial-Derived Short-Chain Carboxylic Acids and Phytoestrogen Metabolites in Peri- and Early Postmenopausal Women.

作者信息

Nosal Briana M, Thornton Staci N, Melnik Alexey V, Lotfi Ali, Mofrad Manije Darooghegi, Aksenov Alexander, Lee Elaine Choung-Hee, Chun Ock K

机构信息

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.

Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.

出版信息

Metabolites. 2024 Oct 11;14(10):541. doi: 10.3390/metabo14100541.

DOI:10.3390/metabo14100541

PMID:39452922

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11509583/

Abstract

OBJECTIVES

The present study aimed to assess the effects of blackcurrant (BC) anthocyanins on concentrations of microbial-derived short-chain carboxylic acids (SCCAs) and metabolites of phytoestrogens. We then examined their associations with six-month changes in whole-body bone mineral density (BMD) and biomarkers of bone metabolism.

METHODS

Fecal and blood samples from a pilot randomized controlled trial were collected and analyzed from 37 eligible peri- and early postmenopausal women aged 45-60 years who were randomized into one of three treatment groups consuming one placebo capsule (control), 392 mg BC (low BC) or 784 mg BC (high BC) daily for six months.

RESULTS

Significant differences were observed between groups at baseline in acetic, propionic, valeric, caproic and heptanoic acids ( < 0.05). Isobutyric acid significantly decreased from baseline (0 months) to six months in the control group ( < 0.05) and the high BC group had a significantly greater concentration than the control group at six months ( < 0.05). Butyric acid was significantly greater in the high BC group than low BC at six months ( < 0.05). Six-month changes in caproic and isobutyric acids showed weak correlations with changes in whole-body BMD (r = 0.3519, < 0.05 and r = 0.3465, < 0.05, respectively). Isovaleric and valeric acids displayed weak correlations with BALP (r = 0.3361, < 0.05) and OPG (r = 0.3593, < 0.05), respectively. Enterodiol was positively correlated with BALP (r = 0.6056, < 0.01) while enterolactone was positively correlated with osteocalcin (r = 0.5902, < 0.001) and negatively correlated with sclerostin (r = -0.3485, < 0.05).

CONCLUSIONS

The results suggest that BC may be a potential dietary agent to reduce postmenopausal bone loss through modulating microbially-derived SCCAs and phytoestrogen metabolites.

摘要

目的

本研究旨在评估黑加仑（BC）花青素对微生物衍生的短链羧酸（SCCAs）浓度和植物雌激素代谢产物的影响。然后，我们研究了它们与全身骨矿物质密度（BMD）六个月变化以及骨代谢生物标志物之间的关联。

方法

从一项初步随机对照试验中收集了37名年龄在45 - 60岁的符合条件的围绝经期和绝经后早期妇女的粪便和血液样本，并进行分析。这些妇女被随机分为三个治疗组之一，分别每天服用一粒安慰剂胶囊（对照组）、392毫克BC（低BC组）或784毫克BC（高BC组），持续六个月。

结果

在基线时，各组之间在乙酸、丙酸、戊酸、己酸和庚酸方面观察到显著差异（<0.05）。对照组中异丁酸从基线（0个月）到六个月显著降低（<0.05），高BC组在六个月时的浓度显著高于对照组（<0.05）。六个月时，高BC组中的丁酸显著高于低BC组（<0.05）。己酸和异丁酸的六个月变化与全身BMD的变化显示出弱相关性（分别为r = 0.3519，<0.05和r = 0.3465，<0.05）。异戊酸和戊酸分别与骨碱性磷酸酶（BALP）（r = 0.3361，<0.05）和骨保护素（OPG）（r = 0.3593，<0.05）显示出弱相关性。肠二醇与BALP呈正相关（r = 0.6056，<0.01），而肠内酯与骨钙素呈正相关（r = 0.5902，<0.001），与硬化蛋白呈负相关（r = -0.3485，<0.05）。