Santos Beatriz Almeida, Corrêa Jaqueline Valença, Latini Carolina Dragone, Tsunemi Miriam Harumi, Alfonso Angélica, Machado Luiz Henrique de Araújo, Lourenço Maria Lucia Gomes
School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Botucatu 18618-681, Brazil.
Institute of Biosciences, São Paulo State University (Unesp), Botucatu 18618-689, Brazil.
Vet Sci. 2024 Oct 1;11(10):467. doi: 10.3390/vetsci11100467.
Myxomatous mitral valve disease (MMVD) is the most prevalent cardiac disease in dogs. This study aimed to compare the arrhythmogenic profile and heart rate variability (HRV) of dogs with MMVD in stages B1 and B2. Electrocardiographic exams and the medical records of 60 dogs were analyzed, and HRV, P wave dispersion, QT interval dispersion, and QT interval instability parameters were determined. The results showed significantly increased values in stage B2 compared with stage B1 ( < 0.05) regarding P wave maximum and minimum duration (Pmax and Pmin) and short-term instability (STI). In contrast, no statistically significant differences were observed regarding HRV parameters, P wave dispersion, or QT interval dispersion. Our findings showed that cardiac remodeling in stage B2 could not significantly alter the sympathovagal balance and showed little interference with the predisposition of arrhythmias in dogs with MMVD.
黏液瘤样二尖瓣疾病（MMVD）是犬类中最常见的心脏疾病。本研究旨在比较处于B1和B2阶段的MMVD犬的致心律失常特征和心率变异性（HRV）。分析了60只犬的心电图检查结果和病历，并测定了HRV、P波离散度、QT间期离散度和QT间期不稳定性参数。结果显示，与B1阶段相比，B2阶段的P波最大和最小持续时间（Pmax和Pmin）以及短期不稳定性（STI）值显著升高（<0.05）。相比之下，在HRV参数、P波离散度或QT间期离散度方面未观察到统计学上的显著差异。我们的研究结果表明，B2阶段的心脏重塑不会显著改变交感迷走神经平衡，并且对MMVD犬的心律失常易感性干扰较小。
