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儿童中枢性睡眠呼吸暂停——三级睡眠实验室的10年经验

Central Sleep Apnea in Children-10 Years Experience at a Tertiary Sleep Laboratory.

作者信息

Yılmaz Yeğit Cansu, Kalyoncu Mine, Yanaz Mürüvvet, Guliyeva Aynur, Selçuk Merve, Karabulut Şeyda, Sabancı Meltem, Ergenekon Pınar, Gökdemir Yasemin, Karakoç Fazilet, Ersu Refika, Karadağ Bülent, Erdem Eralp Ela

机构信息

Division of Pediatric Pulmonology, Marmara University School of Medicine, İstanbul, Türkiye.

Sleep Center, Marmara University School of Medicine, İstanbul, Türkiye.

出版信息

Thorac Res Pract. 2024 Sep 2;25(5):188-192. doi: 10.5152/ThoracResPract.2024.24018.

Abstract

OBJECTIVE

Central sleep apnea (CSA) is a rare condition in children; however, it can cause significant morbidity if not diagnosed early. We aimed to increase the knowledge about CSA in children by describing the clinical characteristics of children diagnosed with CSA at our sleep center.

MATERIAL AND METHODS

We retrospectively reviewed 1263 polysomnographies (PSG) performed between 2012 and 2023 at our tertiary sleep center and evaluated the clinical characteristics of the patients with CSA. Underlying diseases, clinical symptoms, sleep parameters, and short-term management of the patients were recorded.

RESULTS

Of the 1263 patients aged between 1 month and 18 years, 122 (9.65%) had CSA, with 54.9 % (n = 67) of them being female. Only 56.6% (n = 69) of the patients' parents had reported a symptom indicating sleep-disordered breathing. The most common underlying disease was genetic, including Down and Prader-Willi syndromes, followed by neurological diseases . Obstructive sleep apnea was detected in addition to CSA in 103 of the patients (84.4%). Bi-level positive airway pressure with a backup rate was the most common treatment modality.

CONCLUSION

While CSA is a rare clinical condition in children, it occurs more commonly in those with an underlying disease. Awareness of the disease and timely referral of the patients for sleep studies are critical to prevent long-term sequelae.

摘要

目的

中枢性睡眠呼吸暂停(CSA)在儿童中是一种罕见病症;然而,如果不及早诊断,它可能导致严重的发病情况。我们旨在通过描述在我们睡眠中心被诊断为CSA的儿童的临床特征,来增加对儿童CSA的了解。

材料与方法

我们回顾性分析了2012年至2023年在我们三级睡眠中心进行的1263份多导睡眠图(PSG),并评估了CSA患者的临床特征。记录了患者的基础疾病、临床症状、睡眠参数和短期治疗情况。

结果

在1263名年龄在1个月至18岁之间的患者中,122名(9.65%)患有CSA,其中54.9%(n = 67)为女性。只有56.6%(n = 69)的患者家长报告有表明睡眠呼吸紊乱的症状。最常见的基础疾病是遗传性疾病,包括唐氏综合征和普拉德-威利综合征,其次是神经系统疾病。103名患者(84.4%)除CSA外还检测出阻塞性睡眠呼吸暂停。带后备频率的双水平气道正压通气是最常见的治疗方式。

结论

虽然CSA在儿童中是一种罕见的临床病症,但在有基础疾病的儿童中更常见。对该疾病的认识以及及时将患者转诊进行睡眠研究对于预防长期后遗症至关重要。

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