School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China.
Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Nano Lett. 2024 Nov 27;24(47):15092-15100. doi: 10.1021/acs.nanolett.4c04328. Epub 2024 Oct 25.
Real-time and continuous monitoring of physiological status via noninvasive sweat sensing shows promise for personalized healthcare and fitness management. However, the largely varied perspiration rates in different body statuses introduce challenges for effective sweat collection and accurate sensing. Herein, a fully printable strategy was developed to realize fully integrated patches for wireless sensing of sweat biomarker levels and perspiration rates with desirable stability and versatility. The printable calcium sensors with modified ion-selective membranes displayed an ultrawide linear range of 0.1-100 mM and a long-term stability with minimized drift down to 0.083 mV/h for around 40 h. Moreover, the microfluidic channels in versatile configurations were capable of a minimum sweat rate monitoring of 0.5 μL/min and a large sweat storage volume of up to 200 μL. The as-proposed fully printable sensing platforms provide high compatibility for sensor integration to achieve versatile perspiration tracking and comprehensive health monitoring.
通过无创汗液感应实时、连续监测生理状态有望实现个性化医疗保健和健身管理。然而，不同身体状态下的汗液分泌率差异很大，这给有效的汗液收集和准确感应带来了挑战。在此，开发了一种全打印策略，以实现具有理想稳定性和多功能性的无线汗液生物标志物水平和出汗率感应的完全集成贴片。具有改良离子选择性膜的可打印钙传感器具有超宽的线性范围（0.1-100 mM）和长期稳定性，漂移最小可达 0.083 mV/h，持续约 40 小时。此外，多功能配置的微流道能够以 0.5 μL/min 的最小汗液率进行监测，并具有高达 200 μL 的大汗液储存量。所提出的全打印传感平台为传感器集成提供了高兼容性，可实现多功能出汗跟踪和全面健康监测。
