Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Mood Center Paris Saclay, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre F-94275, France; MOODS Team, INSERM 1018, CESP (Centre de Recherche en Epidémiologie et Santé des Populations), Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Le Kremlin Bicêtre F-94275, France.
Université Paris-Saclay, AP-HP, Centre de Recherche Clinique, Hôpitaux Universitaires Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, Le Kremlin Bicêtre F-94275, France.
J Psychosom Res. 2024 Dec;187:111963. doi: 10.1016/j.jpsychores.2024.111963. Epub 2024 Oct 21.
It is unclear whether pre-COVID medical conditions are risk factors for post-COVID major depressive episode (MDE). We aimed to determine which pre-COVID medical conditions are risk factors for post-COVID MDE after a hospitalization for COVID-19.
We conducted a nested retrospective case-cohort study within a cohort of 650 patients evaluated six months after hospitalization for COVID-19 at Bicêtre hospital, France. Nine medical conditions present before COVID-19 (High blood pressure, obesity, type 2 diabetes, cardiac, respiratory and renal disease, immune deficiency, neoplasia and liver disease) were extracted from medical records. MDE was assessed using the Structured Clinical Interview for DSM-5 Disorders-Clinician Version (SCID-5-CV). Bivariate and multivariable analyses were performed to determine which pre-COVID medical conditions are independent risk factors for post-COVID new-onset MDE.
Patients mean age was 62.8 (15.8), 258 (39.7 %) were women; 301 (46.3 %) had high blood pressure, 205 (32.4 %) had obesity, and 186 (28.6 %) had type 2 diabetes. Thirty-six (5.5 %) patients were diagnosed with a new-onset MDE. In contrast to other medical conditions, type 2 diabetes was significantly associated with new-onset MDE (OR = 2.51 [1.19-5.29]).
Unlike other pre-COVID medical conditions, type 2 diabetes is a risk factor for post-COVID MDE. Patients with type 2 diabetes should be screened for MDE after a hospitalization for COVID-19.
目前尚不清楚 COVID-19 之前的疾病是否是 COVID-19 后发生重度抑郁发作（MDE）的危险因素。我们旨在确定 COVID-19 住院后发生 COVID-19 后 MDE 的 COVID-19 之前的哪些疾病是危险因素。
我们在法国比塞特尔医院对 COVID-19 住院后 6 个月进行评估的 650 例患者队列中进行了嵌套的回顾性病例对照研究。从病历中提取了 COVID-19 之前存在的 9 种疾病（高血压、肥胖症、2 型糖尿病、心脏、呼吸和肾脏疾病、免疫缺陷、肿瘤和肝脏疾病）。使用 DSM-5 障碍临床定式访谈-临床医生版（SCID-5-CV）评估 MDE。进行了单变量和多变量分析，以确定 COVID-19 之前的哪些疾病是 COVID-19 后新发 MDE 的独立危险因素。
患者的平均年龄为 62.8（15.8），258 例（39.7％）为女性；301 例（46.3％）有高血压，205 例（32.4％）有肥胖症，186 例（28.6％）有 2 型糖尿病。36 例（5.5％）患者被诊断为新发 MDE。与其他疾病相比，2 型糖尿病与新发 MDE 显著相关（OR=2.51 [1.19-5.29]）。
与其他 COVID-19 之前的疾病不同，2 型糖尿病是 COVID-19 后 MDE 的危险因素。COVID-19 住院后，应筛查 2 型糖尿病患者是否存在 MDE。
