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银屑病皮肤中真皮细胞群体的免疫组织化学研究。

Immunohistochemical study of dermal cell popoulation in psoriatic skin.

作者信息

de Panfilis G, Allegra F

出版信息

Acta Derm Venereol Suppl (Stockh). 1979;87:22-6.

PMID:394546
Abstract

As demonstrated by means of an immunoperoxidase technique, the great majority of the infiltrating mononuclear cells located in the superficial and middle dermis of psoriatic skin consisted of T-lymphocytes. On the contrary, immunoglobulin bearing cells, investigated by means of both immunoperoxidase and immunofluorescence methods, were scarce; IgA and IgG cells were predominant, whilst IgM cells were scarcely represented. Macrophages and monocytic cells were observed in the superficial dermis by means of the alpha-naphtyl-acetate-esterase method, in frozen sections. The role of the above mentioned cells and the significance of their reciprocal relationships still remains in discussion.

摘要

通过免疫过氧化物酶技术证实,位于银屑病皮肤浅真皮层和中真皮层的绝大多数浸润单核细胞由T淋巴细胞组成。相反,通过免疫过氧化物酶和免疫荧光方法检测的含免疫球蛋白细胞很少;IgA和IgG细胞占主导,而IgM细胞几乎没有。在冰冻切片中,通过α-萘基乙酸酯酶法在浅真皮层观察到巨噬细胞和单核细胞。上述细胞的作用及其相互关系的意义仍在讨论中。

相似文献

1
Immunohistochemical study of dermal cell popoulation in psoriatic skin.银屑病皮肤中真皮细胞群体的免疫组织化学研究。
Acta Derm Venereol Suppl (Stockh). 1979;87:22-6.
2
[Immunomorphological and histochemical characteristics of the skin in psoriasis].[银屑病皮肤的免疫形态学和组织化学特征]
Arkh Patol. 1980;42(2):60-4.
3
In situ identification of mononuclear cells infiltrating cutaneous carcinoma: an immuno-histochemical study.皮肤癌中浸润单核细胞的原位鉴定:一项免疫组织化学研究。
Acta Derm Venereol. 1979;59(3):219-22.
4
Plaque psoriasis vs. atopic dermatitis and lichen planus: a comparison for lesional T-cell subsets, epidermal proliferation and differentiation.斑块状银屑病与特应性皮炎和扁平苔藓的比较:病变部位T细胞亚群、表皮增殖和分化情况
Br J Dermatol. 2005 Jul;153(1):72-8. doi: 10.1111/j.1365-2133.2005.06538.x.
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Subpopulations of mononuclear cells in lesions of psoriasis, lichen planus and discoid lupus erythematosus studied using monoclonal antibodies.使用单克隆抗体研究银屑病、扁平苔藓和盘状红斑狼疮皮损中的单核细胞亚群。
Acta Derm Venereol. 1982;62(6):477-83.
6
[Immunopathological studies on psoriasis--on inflammatory infiltrates in the psoriatic lesion].银屑病的免疫病理学研究——关于银屑病皮损中的炎性浸润
Nihon Hifuka Gakkai Zasshi. 1982 Oct;92(11):1139-45.
7
[Detection of IgA in diseased skin and serum of patients with psoriasis vulgaris].
Dermatol Monatsschr. 1990;176(4):225-31.
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Natural killer and natural killer-T cells in psoriasis.银屑病中的自然杀伤细胞和自然杀伤T细胞。
Arch Dermatol Res. 2002 Nov;294(8):363-9. doi: 10.1007/s00403-002-0349-4. Epub 2002 Oct 8.
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[Clinico-immunological correlations in psoriatic arthritis based on data from determining cellular (T- and B-lymphocytes) and humoral (IgG, IgA and IgM) immunity factors].
Vestn Dermatol Venerol. 1981 Sep(9):10-4.
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[The immunology of psoriasis].[银屑病的免疫学]
Ann Dermatol Syphiligr (Paris). 1976;103(5-6):509-23.

引用本文的文献

1
Reappraisal of in situ immunophenotypic analysis of psoriasis skin: interaction of activated HLA-DR+ immunocompetent cells and endothelial cells is a major feature of psoriatic lesions.银屑病皮肤原位免疫表型分析的重新评估:活化的HLA-DR +免疫活性细胞与内皮细胞的相互作用是银屑病皮损的主要特征。
Arch Dermatol Res. 1994;286(2):87-96. doi: 10.1007/BF00370733.
2
Remarks on early versus late lichen planus.关于早期与晚期扁平苔藓的论述
Arch Dermatol Res. 1981;270(2):163-6. doi: 10.1007/BF00408227.
3
Immunocompetent cells in psoriasis. In situ immunophenotyping by monoclonal antibodies.
银屑病中的免疫活性细胞。单克隆抗体原位免疫表型分析。
Arch Dermatol Res. 1983;275(3):181-9. doi: 10.1007/BF00510050.
4
Effect of extracorporeal photopheresis on selected immunologic parameters in psoriasis vulgaris.体外光化学疗法对寻常型银屑病某些免疫参数的影响。
Yale J Biol Med. 1989 Nov-Dec;62(6):653-64.