Vartazarian N D, Avetisian O G
Arkh Patol. 1980;42(2):60-4.
Immunomorphologic and histochemical studies of the skin biopsies withdrawn from patients with psoriasis revealed injury to all the structures of both the epidermis and dermis. Of importance is the immune injury to the microcirculatory bed of the skin, associated with sedimentation of immune complexes, IgA, IgG and C-3 component of the complement on vascular walls, endothelial cells and fibrillar structures of the connective tissue. The inflammatory process involving largely the papillary layer of the dermis is accompanied by increased dermoepidermal permeability with a resultant injury to the epidermis, and by sedimentation of the complexes antigen-antibody and complement in the intercellular spaces of granular and horny layers of the capillaries. These data indicate the participation of the immunopathologic reactions in skin injury produced by psoriasis and their implication in the maintenance of the pathologic process in further disease progress.
对银屑病患者皮肤活检样本进行的免疫形态学和组织化学研究显示，表皮和真皮的所有结构均受到损伤。皮肤微循环床的免疫损伤具有重要意义，这与免疫复合物、IgA、IgG和补体C-3成分在血管壁、内皮细胞和结缔组织纤维结构上的沉积有关。主要累及真皮乳头层的炎症过程伴随着真皮表皮通透性增加，进而导致表皮损伤，同时抗原-抗体复合物和补体在毛细血管颗粒层和角质层的细胞间隙中沉积。这些数据表明免疫病理反应参与了银屑病所致的皮肤损伤，并在疾病进一步发展过程中对病理过程的维持具有重要作用。
