Pelfini C, Jucci A, Fratino P, De Marco R, Serri F
Acta Derm Venereol Suppl (Stockh). 1979;87:48-50.
We have earlier demonstrated that in psoriasis there exists a reduced tolerance to carbohydrates in association with hyperinsulinism. To pursue this problem further, we felt it worthwhile to deal with the results of the oral glucose tolerance test performed on 78 subjects (divided into homogenous groups of normal, obese and psoriatic groups, both with and without diabetic genetic history and obesity) with determinations of both blood glucose and blood insulin levels. We have calculated the insulinogenic indexes by using the techniques elaborated by various authors (I/G, delta I/delta G, AI/AG) and we have then carried out a statistical evaluation both of these indexes and of the ratio between the various indexes employing not only the usual techniques but also that of correlation and simple and multiple regression. We have done this in order to evaluate which of these indexes is better suited to demonstrate the physiopathological mechanism concerning the relationship between insulin hypersecretion and reduced carbohydrate tolerance in the various pathological conditions which we have dealt with.
我们之前已经证明，在银屑病患者中，存在与高胰岛素血症相关的对碳水化合物耐受性降低的情况。为了进一步探讨这个问题，我们认为有必要分析对78名受试者（分为正常、肥胖和银屑病组，均有或无糖尿病遗传史及肥胖）进行口服葡萄糖耐量试验的结果，并测定血糖和血胰岛素水平。我们使用不同作者所阐述的技术（I/G、ΔI/ΔG、AI/AG）计算胰岛素生成指数，然后不仅采用常规技术，还采用相关性以及简单和多元回归技术，对这些指数以及各指数之间的比率进行统计评估。我们这样做是为了评估这些指数中哪一个更适合用于证明我们所研究的各种病理状况下胰岛素分泌过多与碳水化合物耐受性降低之间关系的生理病理机制。
