Goethe University Frankfurt, University Hospital, Department of Nuclear Medicine, Clinic for Radiology and Nuclear Medicine, Frankfurt, Germany.
Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany; Department of Nuclear Medicine and Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.
Mol Metab. 2024 Dec;90:102055. doi: 10.1016/j.molmet.2024.102055. Epub 2024 Oct 23.
Sodium-glucose cotransporters (SGLTs) play a crucial role in glucose regulation and are essential therapeutic targets for diabetes management. Recent advancements have leveraged SGLT-targeted PET imaging to examine these transporters' roles in both health and disease.
This review highlights recent innovations in PET imaging targeting SGLTs, with a particular focus on SGLT-specific radiotracers, such as alpha-methyl-4-deoxy-4-F-fluoro-d-glucopyranoside (Me-4FDG). It emphasizes the advantages of these radiotracers over conventional F-2-fluoro-2-deoxy-d-glucose (2-FDG) imaging, especially in assessing SGLT activity. Additionally, the review addresses their potential in evaluating the pharmacodynamics of SGLT inhibitors, investigating metabolic changes in diabetes, and staging cancers.
SGLT-targeted PET imaging offers promising improvements in diagnostic accuracy and therapeutic planning. The findings underscore the physiological and pathological significance of SGLTs, indicating that this imaging approach could shape future diagnostic and therapeutic strategies in metabolic and oncologic fields.
葡萄糖协同转运蛋白（SGLTs）在葡萄糖调节中发挥着关键作用，是糖尿病管理的重要治疗靶点。最近的进展利用 SGLT 靶向的 PET 成像来研究这些转运体在健康和疾病中的作用。
本文重点介绍了 SGLT 靶向 PET 成像的最新创新，特别关注 SGLT 特异性放射性示踪剂，如 alpha-甲基-4-去氧-4-F-氟-D-吡喃葡萄糖（Me-4FDG）。它强调了这些放射性示踪剂相对于传统的 F-2-氟-2-脱氧-D-葡萄糖（2-FDG）成像的优势，特别是在评估 SGLT 活性方面。此外，该综述还探讨了它们在评估 SGLT 抑制剂的药效动力学、研究糖尿病代谢变化和癌症分期方面的潜力。
SGLT 靶向的 PET 成像在诊断准确性和治疗计划方面提供了有前途的改进。这些发现强调了 SGLTs 的生理和病理意义，表明这种成像方法可能会改变代谢和肿瘤领域的未来诊断和治疗策略。
