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Burn the Fat: Colon Cancer Tumors Are Skilled at Lipid Storage During Obesity.

作者信息

Theiss Arianne L, Williams Christopher S

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado; Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado.

Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee; Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

出版信息

Gastroenterology. 2025 Feb;168(2):215-217. doi: 10.1053/j.gastro.2024.10.021. Epub 2024 Oct 23.

DOI:10.1053/j.gastro.2024.10.021
PMID:39454894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12036317/
Abstract
摘要

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本文引用的文献

1
Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels.肥胖促进的结肠癌进展由二酰甘油O-酰基转移酶1和2水平升高介导。
Gastroenterology. 2025 Feb;168(2):286-299.e6. doi: 10.1053/j.gastro.2024.09.011. Epub 2024 Sep 18.
2
The role of DGAT1 and DGAT2 in regulating tumor cell growth and their potential clinical implications.DGAT1 和 DGAT2 在调节肿瘤细胞生长中的作用及其潜在的临床意义。
J Transl Med. 2024 Mar 18;22(1):290. doi: 10.1186/s12967-024-05084-z.
3
Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism.肥胖诱导的癌细胞及其微环境变化：调控脂质代谢紊乱的机制和治疗观点。
Semin Cancer Biol. 2023 Aug;93:36-51. doi: 10.1016/j.semcancer.2023.05.002. Epub 2023 May 6.
4
Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?为何作为一种炎症状态的肥胖会易患结直肠癌？
J Clin Med. 2023 Mar 23;12(7):2451. doi: 10.3390/jcm12072451.
5
Association Between Metabolic Syndrome and the Risk of Colorectal Cancer Diagnosed Before Age 50 Years According to Tumor Location.根据肿瘤位置，代谢综合征与 50 岁前诊断的结直肠癌风险之间的关联。
Gastroenterology. 2022 Sep;163(3):637-648.e2. doi: 10.1053/j.gastro.2022.05.032. Epub 2022 May 25.
6
Factors Associated With Geographic Disparities in Gastrointestinal Cancer Mortality in the United States.与美国胃肠道癌死亡率的地理差异相关的因素。
Gastroenterology. 2022 Aug;163(2):437-448.e1. doi: 10.1053/j.gastro.2022.04.019. Epub 2022 Apr 25.
7
Tumour fatty acid metabolism in the context of therapy resistance and obesity.治疗抵抗和肥胖背景下的肿瘤脂肪酸代谢
Nat Rev Cancer. 2021 Dec;21(12):753-766. doi: 10.1038/s41568-021-00388-4. Epub 2021 Aug 20.
8
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
9
Unraveling the Etiology of Early-Onset Colorectal Cancer.解析早发性结直肠癌的病因
J Natl Cancer Inst. 2021 May 4;113(5):505-506. doi: 10.1093/jnci/djaa165.
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Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-14. doi: 10.1200/EDBK_279901.